{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:15:38Z","timestamp":1777666538478,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    The potential of Picroliv, a herbal extract against acute cadmium (Cd) intoxication, was evaluated in male rats. Biochemical and histopathological profile in rats pretreated with Picroliv (12 mg\/kg, oral) followed by a single dose of Cd as cadmium chloride (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    ) (3 mg\/kg, ip) revealed marked suppression of oxidative stress in liver and testes. The Cd-induced enhanced levels of lipid peroxidation, membrane fluidity and reduced levels of nonprotein sulphydryls and Na\n                    <jats:sup>+<\/jats:sup>\n                    K\n                    <jats:sup>+<\/jats:sup>\n                    ATPase were significantly restored to near normal by Picroliv pretreatment. In addition, the Cd-induced serum levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, gamma glutamyl transpeptidase and lactate dehydrogenase were restored to near basal levels. Hepatic and testicular histopathological damage was also minimized. The results strongly suggest definite hepatoand testicular protection by Picroliv. The antioxidant potential of the herbal extract in the major part, and not its chelating property, seems to be responsible for its ameliorative action.\n                  <\/jats:p>","DOI":"10.1191\/0960327105ht563oa","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T17:10:37Z","timestamp":1128618637000},"page":"529-536","source":"Crossref","is-referenced-by-count":16,"title":["Prevention of acute cadmium toxicity by Picroliv"],"prefix":"10.1177","volume":"24","author":[{"given":"N","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K S","family":"Dogra","sequence":"additional","affiliation":[{"name":"Industrial Toxicology Research Centre, P.O. Box 80, M.G. Marg, Lucknow                         226001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Y","family":"Khan","sequence":"additional","affiliation":[{"name":"Dr RML Avadh University, Faizabad 224001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Immunotoxicology Division, Industrial Toxicology Research Centre, P.O.                         Box 80, M.G. Marg, Lucknow 226001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"atypb1","first-page":"189","volume-title":"Handbook of experimental pharmacology: toxicology of metals, biochemical effects","author":"Goering PL","year":"1994"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1080\/009841099157296"},{"key":"atypb3","first-page":"119","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","author":"IARC","year":"1993"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8586"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(87)90134-2"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)90032-2"},{"key":"atypb7","first-page":"400","volume":"266","author":"Liu Y","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb8","first-page":"595","volume":"5","author":"Dhawan BN","year":"1995","journal-title":"Res Med Chem"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(01)00259-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00144-9"},{"key":"atypb11","first-page":"564","volume":"40","author":"Khandelwal S","year":"2002","journal-title":"Indian J Exp Biol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(01)00264-7"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00268-3"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00203-3"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200302000-00014"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"atypb18","first-page":"481","volume":"24","author":"Bergmeyer HU","year":"1986","journal-title":"J Clin Chem Clin Biochem"},{"key":"atypb19","first-page":"497","volume":"24","author":"Bergmeyer HU","year":"1986","journal-title":"J Clin Chem Clin Biochem"},{"key":"atypb20","first-page":"2\/2","volume-title":"Proc Int Semin Workshop Enzymol","author":"Bowers GN","year":"1972"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50039-6"},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1056\/NEJM195609062551001","volume":"225","author":"Wacker WEC","year":"1956","journal-title":"N Engl J Med"},{"key":"atypb23","unstructured":"23                      Colowick SP                 ,                      Kaplan NO                 . 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