{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:32:26Z","timestamp":1794047546638,"version":"4.8.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[1999,9]]},"abstract":"<jats:p>1 Chloramphenicol has been widely used in the treatment of serious infections including typhoid fever and meningitis. However, the drug is haemotoxic in man inducing firstly, a reversible, dose-dependent anaemia which develops during treatment, secondly, an often fatal aplastic anaemia with pancytopenia and acellular marrow, and thirdly, leukaemia. 2 We investigated the haemotoxicity of chloramphenicol succinate (CAPS) in female CD-1 mice in repeat dose studies, to compare the response with the reversible anaemia reported in man. Studies in male Wistar Hanover rats were also carried out. 3 CAPS was gavaged daily to mice at dose levels from 800\u20132000 mg\/kg for seven days. Values were significantly reduced for reticulocytes at 1700 and 2000 mg\/ kg, and for erythrocytes (RBC), haematocrit (HCT), and haemoglobin (Hb) at 2000 mg\/kg. Platelet and white blood cell (WBC) counts were unaffected. 4 Mice were dosed with CAPS at 1400 mg\/kg for 10 days and sampled at 1, 4 and 15 days after the last dose. At day 1 post dosing, RBC, HCT and Hb values were significantly reduced, but returned to normal (or above normal) by day 4 or 15. 5 CAPS from 2000\u20134000 mg\/kg was gavaged to rats daily for 19 days. Hb values were significantly lower at 3600 and 4000 mg\/kg; reticulocytes were not reduced. WBC and platelet counts, in general, were unaffected. 6 Levels of apoptosis in marrow mononuclear cells were increased in CAPS-treated mice, but not in CAPS-treated rats. Serum biochemistry parameters, in general, showed few changes of toxicological significance. 7 We conclude that the administration of CAPS to CD-1 mice induced haematological changes showing close parallels with the chloramphenicol-induced reversible anaemia seen in man.<\/jats:p>","DOI":"10.1191\/096032799678845098","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T19:38:43Z","timestamp":1049398723000},"page":"566-576","source":"Crossref","is-referenced-by-count":29,"title":["Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar                 Hanover rat"],"prefix":"10.1177","volume":"18","author":[{"given":"J A","family":"Turton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Yallop","sequence":"additional","affiliation":[{"name":"Centre for Toxicology, Department of Pharmacology, The School of                         Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Fagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"York","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Williams","sequence":"additional","affiliation":[{"name":"GlaxoWellcome Research and Development, Park Road, Ware, Herts SG12 0DP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.02910350003002"},{"key":"atypb2","volume-title":"Martindale. The Extra Pharmacopoeia","author":"Reynolds JEF","year":"1989","edition":"29"},{"key":"atypb3","first-page":"181","volume":"3","author":"Chaplin S","year":"1986","journal-title":"Adverse Drug Reactions and Acute Poisoning Reviews"},{"key":"atypb4","volume-title":"Aplastic Anemia: Acquired and Inherited","author":"Young NS","year":"1994"},{"key":"atypb5","first-page":"169","volume-title":"Chloramphenicol","year":"1990"},{"key":"atypb6","series-title":"WHO Food Additives Series 23","first-page":"1","volume-title":"Toxicological Evaluation of Certain Veterinary Drug Residues in Food","author":"FAO\/WHO Expert Committee on Food Additives","year":"1988"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195507072530102"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196506032722201"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-33-6-1459"},{"key":"atypb10","first-page":"607","volume":"4","author":"Welch H","year":"1954","journal-title":"Antibiotics and Chemotherapy"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160110017004"},{"key":"atypb12","first-page":"138","volume":"4","author":"Yunis AA","year":"1964","journal-title":"Progress in Haematology"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196711092771904"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00368113"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02642503"},{"key":"atypb16","first-page":"8","volume":"17","author":"Holt DE","year":"1998","journal-title":"Human and Experimental Toxicology"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V44.1.49.49"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00955.x"},{"key":"atypb19","first-page":"253","volume":"4","author":"Morley AA","year":"1978","journal-title":"Blood Cells"},{"key":"atypb20","first-page":"53","volume":"17","author":"Yallop D","year":"1998","journal-title":"Human and Experimental Toxicology"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33756-1"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984528"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1159\/000137348"},{"key":"atypb24","first-page":"3478","volume":"41","author":"Robin E","year":"1981","journal-title":"Cancer Research"},{"key":"atypb25","first-page":"646","volume":"64","author":"Bhoopalam N","year":"1986","journal-title":"Clinical and Experimental Immunology"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830050207"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1159\/000237968"},{"key":"atypb28","first-page":"264","volume":"2","author":"Firkin FC","year":"1974","journal-title":"Experimental Haematology"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102184"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90298-5"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196010132631503"},{"key":"atypb32","first-page":"247","volume":"57","author":"Saidi P","year":"1961","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196506032722201"},{"key":"atypb34","first-page":"298","volume":"94","author":"Schrober R","year":"1972","journal-title":"Archives of Pathology"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1258\/002367795780740393"},{"key":"atypb36","first-page":"180","volume":"110","author":"Alison PM","year":"1987","journal-title":"Journal of Clinical Medicine"},{"key":"atypb37","first-page":"378","volume":"92","author":"Reddy J","year":"1980","journal-title":"New Zealand Medical Journal"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1159\/000128196"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1128\/JB.55.3.425-448.1948"},{"key":"atypb40","first-page":"1642","volume":"23","author":"Philpott NJ","year":"1995","journal-title":"Experimental Haematology"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1177\/096032719701601004"},{"key":"atypb42","first-page":"146","volume":"18","author":"Mandal B","year":"1982","journal-title":"Annals of the National Academy of Medical Sciences (India)"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103716"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1963.03860050134016"},{"key":"atypb45","first-page":"357","volume":"15","author":"Yunis A","year":"1969","journal-title":"Advances in Internal Medicine"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096032799678845098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096032799678845098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:53Z","timestamp":1777448813000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/096032799678845098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["10.1191\/096032799678845098"],"URL":"https:\/\/doi.org\/10.1191\/096032799678845098","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}