{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:48:57Z","timestamp":1761918537183,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p> Several case reports and uncontrolled trials have established the use of cyclosporine A (CsA) in systemic lupus erythematosus (SLE) but some concerns have been raised because of its kidney damaging effects. We here report the results of a retrospective follow-up study designed to assess the safety profile and causes of discontinuation due to adverse events in SLE patients treated with CsA. <\/jats:p><jats:p> We treated 56 SLE patients with oral CsA at doses of 3 \u00b1 5 mg\/kg for an average of 26 months. Adverse events not leading to the discontinuation of therapy were observed in 62.5% of the patients, the most frequent being hypertrichosis. CsA was stopped because of the occurrence of side effects in 9=56 (16%) of the patients. The most common were nephrotoxicity (3=9) and the occurrence of tremors (3=9). These effects were always reversible within three months of CsA withdrawal. The patients who were older than 40 y had a significant slightly increased risk of stopping CsA therapy for any adverse events (RR 1.08; CI 95% 1.03 \u00b1 1.14). <\/jats:p><jats:p> In comparison with previous studies, this study involved a larger cohort of SLE patients who were evaluated for a longer period of follow-up, and confirmed the good tolerability of CsA in these subjects. <\/jats:p>","DOI":"10.1191\/096120300676096627","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"676-680","source":"Crossref","is-referenced-by-count":18,"title":["Safety profile and causes of withdrawal due to adverse events in                 systemic lupus erythematosus patients treated long-term with cyclosporine A"],"prefix":"10.1177","volume":"9","author":[{"given":"F","family":"Conti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Priori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F R","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Terapia Medica, Cattedra di Reumatologia,                         Universita\u00c1 degli Studi di Roma `La Sapienza' Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Medda","sequence":"additional","affiliation":[{"name":"Istituto Superiore di Sanita\u00c1, Laboratorio di Epidemiologia e                         Biostatistica, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Valesini","sequence":"additional","affiliation":[{"name":"Dipartimento di Terapia Medica, Cattedra di Reumatologia, Universita                         \u00c1 degli Studi di Roma `La Sapienza', Policlinico Umberto I, 00161                         Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"atypb1","first-page":"1291","volume-title":"Goodman E and Gilman's The Pharmacological Basis of Therapeutics","author":"Diasio 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