{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:08:03Z","timestamp":1762520883734,"version":"3.38.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p> Objective: To better define the serology of a panel of sera from patients with a clinical diagnosis of systemic lupus erythematosus (SLE) or subacute cutaneous lupus erythematosus (SCLE) with a negative antinuclear antibody (ANA) test on mouse liver. <\/jats:p><jats:p> Methods: Sensitive ELISA methods for anti-Ro\/SSA, anti-La\/SSB, and anti-U<jats:sub>1<\/jats:sub>RNP were applied to a panel of 76 sera with either SLE or SCLE and a negative ANA test on mouse liver. <\/jats:p><jats:p> Results: These sera had previously been shown to have a high prevalence of anti-Ro\/SSA (68%) and anti-La\/SSB (27%) precipitins respectively. None had precipitins to U<jats:sub>1<\/jats:sub>RNP or Sm. ELISA methodology revealed that all of the sera 76=76 (100%) had elevated levels (Mean\u00b12SDofa panel of 21 normal sera) of anti-Ro\/SSA, 36=76 (46%) had elevated levels of anti-La\/SSB, and 27 of 76 (35%) had elevated levels of anti-U<jats:sub>1<\/jats:sub>RNP. <\/jats:p><jats:p> Conclusion: The subset of patients with SLE and SCLE with a negative ANA test on mouse liver almost uniformly have antibodies to the Ro\/SSA antigen by a sensitive ELISA. This adds evidence to the idea that this is a more homogeneous disease subset within the spectrum of SLE. <\/jats:p>","DOI":"10.1191\/096120300678828091","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"116-119","source":"Crossref","is-referenced-by-count":46,"title":["ANA negative systemic lupus erythematosus sera revisited serologically"],"prefix":"10.1177","volume":"9","author":[{"given":"Morris","family":"Reichlin","sequence":"first","affiliation":[{"name":"Oklahoma Medical Research Foundation, 825 NE, 13th Street, Oklahoma City,                         OK, 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198103000-00002"},{"key":"atypb2","first-page":"34","volume":"6","author":"Gilliam JN","year":"1977","journal-title":"Continuing Education for the Family Physician"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010120007006"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-664"},{"key":"atypb5","first-page":"161","volume":"49","author":"Reichlin M","year":"1986","journal-title":"Trans Assoc Am Physicians"},{"key":"atypb6","first-page":"309","volume":"11","author":"Harley JB","year":"1984","journal-title":"J Rheumatol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350609"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-596922-2.50012-5"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/61.4.495"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197103000-00001"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90181-X"},{"key":"atypb12","first-page":"142","volume":"5","author":"Gladman DD","year":"1978","journal-title":"J Rheumatol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196407232710401"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200803"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(89)90164-9"},{"key":"atypb16","first-page":"373","volume":"76","author":"Reichlin M","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"atypb17","first-page":"190","volume":"37","author":"Wasicek CA","year":"1979","journal-title":"Clin Exp Immunol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120300678828091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120300678828091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T16:22:36Z","timestamp":1740932556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/096120300678828091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1191\/096120300678828091"],"URL":"https:\/\/doi.org\/10.1191\/096120300678828091","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"type":"print","value":"0961-2033"},{"type":"electronic","value":"1477-0962"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}