{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:04:44Z","timestamp":1764259484677,"version":"3.38.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p> Antiphospholipid antibodies (aPL) have been reported not only in autoimmune disorders but also in various infectious diseases. Accumulating evidence indicates that b<jats:sub>2<\/jats:sub> glycoprotein I (b<jats:sub>2<\/jats:sub>GPI) and prothrombin are the main proteins to which autoimmune aPL bind. The aim of this study was to evaluate the prevalence of different aPL in patients with leprosy. We included 51 outpatients (42 lepromatous and 9 borderline leprosy) without any clinical feature of the antiphospholipid syndrome (APS). 35 had lupus anticoagulant and 31 had anticardiolipin antibodies (aCL). Anti-\u03b22GPI antibodies were highly positive in 29=51 and anti-prothrombin antibodies (anti-II) were detected in 23=51. Almost all aCL and anti-b<jats:sub>2<\/jats:sub>GPI were of IgM isotype, while IgG isotype was more frequent among anti-II. No statistical difference was found when aPL were evaluated in patients grouped according to their bacteriological status. Furthermore, patients under treatment (n \u2018 33) had a similar frequency of positive aPL compared to patients in vigilance (n \u2018 14). Assessing the specificity of antibody binding to CL and b<jats:sub>2<\/jats:sub>GPI in ELISA by means of inhibition studies with cardiolipin-b<jats:sub>2<\/jats:sub>GPI liposomes, leprosy and APS sera showed a similar behaviour. Comparable results were also found in both groups of patients when inhibition experiments with lysate of Mycobacterium leprae were carried out. In summary, leprosy-related aPL resemble those found in patients with APS but the immunoglobulin isotype is different, with IgM much more prevalent in leprosy patients. <\/jats:p>","DOI":"10.1191\/096120300678828712","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"594-600","source":"Crossref","is-referenced-by-count":47,"title":["High prevalence of antiphospholipid antibodies in leprosy: evaluation of                 antigen reactivity"],"prefix":"10.1177","volume":"9","author":[{"given":"G F","family":"de Larra\u00f1aga","sequence":"first","affiliation":[{"name":"Section of Biochemistry, Thrombosis and Haemostasis, Hospital of                         Infectious Diseases FJ Mu\u00f1iz, Buenos Aires, Argentina; G de                         Larran Antiphospholipid antibodies in leprosy GF de Larra\u00f1aga                         Section Bioqu\u00edmica-Hemostasia y Trombosis, Hospital de                         Enfermedades Infecciosas \u2018FJ Mu\u00f1iz\u2019,                         Uspallata 2272, (1282) Buenos Aires, Argentina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R R","family":"Forastiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Martinuzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L O","family":"Carreras","sequence":"additional","affiliation":[{"name":"Division of Haematology, Favaloro University, Favaloro Foundation, Buenos                         Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tsariktsian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Sturno","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Hospital of Infectious Diseases FJ                         Mu\u00f1iz, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B S","family":"Alonso","sequence":"additional","affiliation":[{"name":"Section of Biochemistry, Thrombosis and Haemostasis, Hospital of                         Infectious Diseases FJ Mu\u00f1iz, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,10,1]]},"reference":[{"key":"atypb1","first-page":"373","volume-title":"Phospholipid-Binding Antibodies","author":"Harris EN","year":"1991"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91374-J"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390903"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4049\/jimmunol.154.2.954","volume":"154","author":"Roubey RAS","year":"1995","journal-title":"J 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