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However, small uncontrolled studies of patients with SLE have shown favourable results with a significant improvement in disease activity, a fall in anti ds DNA titres and proteinuria and an improvement in complement levels,leucopaenia and thrombocytopaenia. Interestingly, a consistent reduction in corticosteroid dosage often by as much as 50% is seen. Toxicity, especially with hypertension and renal impairment, occurs but usually reverses on dose reduction or the addition of an anti-hypertensive agent and isminimised by adherence to the strict monitoring guidelines.Large multi-centre randomised-controlled trials of the use of cyclosporin in SLE patients are underway and the results are eagerly awaited. <\/jats:p>","DOI":"10.1191\/096120301672970034","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"165-170","source":"Crossref","is-referenced-by-count":53,"title":["The treatment of lupus with cyclosporin A"],"prefix":"10.1177","volume":"10","author":[{"given":"B","family":"Griffiths","sequence":"first","affiliation":[{"name":"Department of Rheumatology, The University of Leeds, Leeds, UK;                         Rheumatologyand Rehabilitation Research Unit, 36 Clarendon Road, Leeds LS2                         9NZ, UK. 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