{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:56:17Z","timestamp":1793084177496,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>We conducted a randomized, controlled study to assess the need for hydroxychloroquine                 (HCQ) during lupus pregnancy and to assess safety. Twenty consecutive pregnant                 patients with similar characteristics were enrolled. The HCQ group included eight                 patients with systemic lupus erythematosus (SLE) and two with discoid lupus                 erythematosus (DLE). The placebo (PL) group included nine patients with SLE and one                 with DLE. The HCQ group had no flare-ups. SLEPDAI scores were similar at study                 entry, and at conclusion the placebo group had significantly higher scores. One                 patient had improvement of skin lesions and another of arthritis, allowing a                 decrease of prednisone dose. There were no retinal effects. Three patients in the PL                 group flared up, two with skin rashes, one also with arthritis and uveitis, and one                 (previously in remission on HCQ) with hemolytic anemia, polyserositis and anti-dsDNA                 antibody. Toxemia was diagnosed in only three patients in the PL group (one fetal                 death). Comparing prednisone dosage change, we noted a decrease in the HCQ and an                 increase in the PL group. Delivery age and Apgar scores were higher in the HCQ                 group. Neonatal examination did not reveal congenital abnormalities, nor did a                 neuroophthalmological and auditory evaluation at 1.5\u20133 y of age. In spite                 of the small number of patients studied, we noted beneficial effects of HCQ during                 lupus pregnancy, as measured by SLEPDAI and decrease in prednisone dose with no                 detriment to patients' health.<\/jats:p>","DOI":"10.1191\/096120301678646137","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T07:45:16Z","timestamp":1068623116000},"page":"401-404","source":"Crossref","is-referenced-by-count":340,"title":["Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and                 placebo-controlled study"],"prefix":"10.1177","volume":"10","author":[{"given":"R A","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Faculdade de Ci\u00eancias                         M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil; Hospital Universit\u00e1rio Pedro Ernesto, UERJ,                         Discipline of Rheumatology, Blvd 28 de Setembro 77\/333, Vila Isabel                         20550-013, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V S","family":"Vilela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculdade de Ci\u00eancias                         M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculdade de Ci\u00eancias                         M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J LMB","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculdade de Ci\u00eadicas, Universidade                         do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R","family":"Tura","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Faculdade de Ci\u00eancias                         M\u00e9ncias, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E MN","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculdade de Ci\u00eancias                         M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N R","family":"Jes\u00fas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Faculdade de Ci\u00eancias                         M\u00e9dicas, Universidade do Estado do Rio de Janeiro, Rio de                         Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,6]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.2.133"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341210"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.799"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203396005001031"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199101173240309"},{"key":"e_1_2_1_6_1","first-page":"983","article-title":"Aspects of use of antimalarials in systemic lupus erythematosus","volume":"25","author":"Gladman DD","year":"1998","unstructured":"Gladman DD , Urowitz MB , Senecal JL et al. Aspects of use of antimalarials in systemic lupus erythematosus . 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Hydroxychloroquine in pregnant patients with systemic lupus erythematosus . J Rheumatol 1996; 23: 1715\u20131718 .","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.7.486"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203396005001151"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999371"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120399680411272"},{"key":"e_1_2_1_20_1","volume-title":"Goodman and Gilman's: the                     Pharmacological Basis of Therapeutics","author":"Hardman JG","year":"1996","unstructured":"Hardman JG , Limbird JE , Molinoff PB , Ruddon RW , Gilman AG . Antimalarials. In: Goodman and Gilman's: the Pharmacological Basis of Therapeutics. 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Arthritis Rheum 1982; 25: 1272\u20131277 .","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_24_1","first-page":"1390","article-title":"Ophthalmological monitoring of patients taking antimalarials: preferred                         practice patterns","volume":"24","author":"Easterbrook M","year":"1997","unstructured":"Easterbrook M , Bernstein H . Ophthalmological monitoring of patients taking antimalarials: preferred practice patterns . J Rheumatol 1997; 24: 1390\u20131392 .","journal-title":"J Rheumatol"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.5.599"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120301678646137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120301678646137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:40:27Z","timestamp":1767631227000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/096120301678646137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1191\/096120301678646137"],"URL":"https:\/\/doi.org\/10.1191\/096120301678646137","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}