{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:22:31Z","timestamp":1784337751879,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p> The antiphospholipid antibody syndrome (APS) is characterized by arterial or venous thromboses and recurrent foetal loss. It occurs as primary disease, but also in the context of systemic lupus erythematosus (SLE). Whereas primary APS induces a thrombotic microangiopathy without significant inflammatory reaction, secondary APS in SLE is usually associated with vasculitis. Here we report a patient with APS who presented with acute diarrhoea and then developed a HELLP-like syndrome characterized by a spontaneous abortion, multifocal hepatic necroses and thrombocytopenia. Thereafter an acute flare of SLE with arthralgias, pleuritis, skin rash and glomerulitis occurred. Clinical amelioration was only achieved by combining curettage, antic-oagulation and immunosuppression, a treatment taking into account the pathogenesis of HELLPlike disease, APS and SLE. To our knowledge this is the first reported case of APS associated with combined acute manifestations of these three syndromes triggered by a presumable intestinal infection. <\/jats:p>","DOI":"10.1191\/096120301701549606","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"576-579","source":"Crossref","is-referenced-by-count":20,"title":["Foetal loss, liver necrosis and acute lupus erythematosus in a patient with                 antiphospholipid antibody syndrome"],"prefix":"10.1177","volume":"10","author":[{"given":"T","family":"Fehr","sequence":"first","affiliation":[{"name":"Medical Clinic B, University Hospital, Zurich, Switzerland; Department of                         Internal Medicine, University Hospital, Ra\u00e8mistrasse 100, CH-8091                         Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Cathomas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, University Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schaffner","sequence":"additional","affiliation":[{"name":"Medical Clinic B, University Hospital, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"issue":"58","key":"atypb1","first-page":"20","volume":"27","author":"Myones BL","year":"2000","journal-title":"J Rheumatol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6398.1021"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10362-8"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/096120339800700222"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199805000-00005"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500506"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-9-682"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00098-1"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600615"},{"key":"atypb11","first-page":"1360","volume":"21","author":"Ornstein MH","year":"1994","journal-title":"J Rheumatol"},{"key":"atypb12","first-page":"1138","volume":"81","author":"Rolfes DB","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.772"},{"key":"atypb14","first-page":"238","volume":"27","author":"Rojas-Rodriguez J","year":"2000","journal-title":"J Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120301701549606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120301701549606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T19:05:57Z","timestamp":1740855957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/096120301701549606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1191\/096120301701549606"],"URL":"https:\/\/doi.org\/10.1191\/096120301701549606","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}