{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:44:49Z","timestamp":1761518689132,"version":"3.38.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2002,5]]},"abstract":" B cells from patients with systemic lupus erythematosus (SLE) display increased responses following cross-linking of the surface antigen receptor. We explored the possibility that the increased responses are at least partially due to simultaneous cross-linking of the complement receptor 2 (CR2). To this end, we stimulated fresh B cells from SLE patients with an anti-IgD antibody conjugated to the Epstein\u2013Barr virus gp350 protein, which binds to CR2, and recorded the free intracytoplasmic calcium response during the first 10 min. Despite the fact that SLE B cells were found to express half as many surface CR2 as normal B cells, both peak responses and the percentage of responding cells were significantly increased in the former. These observations suggest that regulatory molecules such as CR2 are involved in the increased B cell responses in SLE patients. We propose that certain immune complexes that circulate in the sera of SLE patients that have anti-surface immunoglobulin specificities and are decorated with natural ligands of CR2, such as C3d, elicit and promote B cell overactivity. <\/jats:p>","DOI":"10.1191\/0961203302lu188oa","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T20:07:41Z","timestamp":1034366861000},"page":"299-303","source":"Crossref","is-referenced-by-count":11,"title":["Engagement of complement receptor 2 on the surface of B cells from patients with systemic lupus erythematosus contributes to the increased responsiveness to antigen stimulation"],"prefix":"10.1177","volume":"11","author":[{"given":"J P","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Enyedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lees","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA; Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA; WRAIR, Bldg 503, Rm 1A32"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"atypb1","unstructured":"Liossis SN , Tsokos GC . In: Wallace DJ , Hahn BH (eds). B-cell Abnormalities in Systemic Lupus Erythematosus, 6th edn. 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