{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:49:12Z","timestamp":1781304552029,"version":"3.54.1"},"reference-count":91,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p> It is well known that women with systemic lupus erythematosus (SLE) who have antiphospholipid antibodies (aPL) are at increased risk for pregnancy loss. Additionally, other reproductive processes, such as unexplained infertility and implantation failure after in vitro fertilization and embryo transfer may be affected by aPL. Thus, clinical manifestations of the so-called \u2018gynaecoobstetrical antiphospholipid syndrome\u2019 have been expanded into the concept of the \u2018reproductive autoimmune failure syndrome\u2019. However, this is still a matter of debate with no general agreement with respect to both pathophysiological signi\u201d cance of the presence of aPL and patient management. This article analyses a number of controversies in the management of reproductive failure potentially associated with aPL in order to help clinicians dealing with such condition in daily clinical practice. <\/jats:p>","DOI":"10.1191\/0961203302lu237ra","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:10Z","timestamp":1033509850000},"page":"467-477","source":"Crossref","is-referenced-by-count":15,"title":["Reflections on the management of reproductive failure in the                 antiphospholipid syndrome\u2014the clinician\u2019s perspective"],"prefix":"10.1177","volume":"11","author":[{"given":"J","family":"Balasch","sequence":"first","affiliation":[{"name":"Institut Cl\u00ednic of Gynaecology, Obstetrics and Neonatology,                         Catalonia, Spain; Institut Cl\u00ednic of Gynaecology and Obstetrics,                         Hospital Cl\u00ednic C\/Casanova 143, 08036-Barcelona, Catalonia,                         Spain.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Cervera","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Institut Cl\u00f5\u00e1nic                         of Infections and Immunology, Faculty of Medicine, University of Barcelona,                         Hospital Cl\u00f5\u00e1nic-Institut d0Investigacions                         Biome`diques August Pi i Sunyer, Barcelona,Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196207262670401"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0015-0282(16)56159-7","volume":"60","author":"Kutteh WH","year":"1993","journal-title":"Fertil Steril"},{"key":"atypb3","first-page":"117","volume-title":"Progress in Reproductive Medicine","author":"Balasch 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