{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:05:51Z","timestamp":1765886751883,"version":"3.38.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p> High prevalence of coeliac disease (CD) has been reported in various autoimmune disorders, but has not been studied in the antiphospholipidsyndrome (APS). We aimed to establishthe prevalenceof CD antibodiesin a cohort of APS patients, and to examine whether CD may be responsiblefor some of the manifestationsof APS. Fifty-seven patients (47 females, 10 males) with APS were studied for clinical manifestations and serological markers of the disease, as well as the presence of anti-endomysial antibodies using an ELISA assay (EMA-ELISA). Control subjects were 171 healthy individuals, ageand sex-matched (141 females). Eight patients with APS (14%, six females) were found to have EMA-ELISA antibodies, compared with 2\/141 (1.1%) of controls (P 0.0003). Antibodies against b2-glycoprotein-I (b2GPI) epitopes (GRTCPKPDDLP) were more prevalent in EMA-positive patients than in EMA-negative patients (P 0.006). Vasculitic skin lesions were significantly more common in EMA-ELISA-positive compared with EMA-ELISA-negative patients (62.5 versus 16.3%, P 0.01). Among the skin manifestations, superficial cutaneous necrosis (37.5 versus 2%, P 0.007) was more prevalent in EMA-ELISA-positive than in EMA-ELISA-negative patients. EMA-ELISA antibodies are common in APS, and their presence is associated with high prevalence of antibodies recognizing certain b2-glycoprotein epitopes, and with cutaneous manifestations of APS. <\/jats:p>","DOI":"10.1191\/0961203303lu384oa","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T01:58:58Z","timestamp":1051149538000},"page":"394-399","source":"Crossref","is-referenced-by-count":21,"title":["The prevalence of coeliac disease antibodies in patients with the                 antiphospholipid syndrome"],"prefix":"10.1177","volume":"12","author":[{"given":"R","family":"Shamir","sequence":"first","affiliation":[{"name":"Division of Paediatric Gastroenterology and Nutrition, Meyer                         Children\u2019s Hospital of Haifa, Haifa, Israel,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Diseases and Department of Medicine 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