{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:47:18Z","timestamp":1777452438328,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p> Although a few reports in recent years have suggested that patients with antiphospholipid antibodies (aPL) are proneto developingprimaryanetoderma(PA), it is still unclearhowoften aPL are detectedin unselected PA patients. We studied nine consecutive PA patients for the presence of autoimmune antibodies and disorders in general and the presence of aPL in particular. Six of the nine patients had clinical evidence of associated autoimmune disorders (Graves\u2019disease and autoimmune haemolysis in one, systemic scleroderma in one, Hashimoto\u2019s thyroiditisin one, alopecia areata in one) and\/or signs of hypercoagulability (recurrent fetal loss in two, recurrent strokes in one, recurrent deep vein thrombosis in one). In four of these six patients the onset of PA preceded these signs. Positive aPL was foundin all: anticardiolipin(aCL) in six, anti-\u03b2<jats:sub>2<\/jats:sub>-glycoprotein-I(a\u03b2<jats:sub>2<\/jats:sub> GPI) in six and lupusanticoagulant (LAC) in four. The most frequent isotype was IgA. Among other autoantibodies found the most frequentlywas antinuclearantibodies.Four of theninepatientsfulfilled thecriteriaforantiphospholipid syndrome (APS). It is concluded that PA is an important cutaneous sign for autoimmune disorders in general and the presence of aPL in particular. Hence, the work-up of these patients should include testingfor LAC as well as forall differentisotypesof aCL anda\u03b2<jats:sub>2<\/jats:sub> GPI. We recommendthat PA be added to the list of the cutaneous manifestations of APS. <\/jats:p>","DOI":"10.1191\/0961203303lu403oa","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T22:53:15Z","timestamp":1058223195000},"page":"564-568","source":"Crossref","is-referenced-by-count":20,"title":["Primary anetoderma: a cutaneous sign of antiphospholipid antibodies"],"prefix":"10.1177","volume":"12","author":[{"given":"E","family":"Hodak","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petah                         Tiqva, Israel,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Feuerman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petah                         Tiqva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Molad","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Monselise","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology, Rabin Medical Center, Beilinson                         Campus, Petah Tiqva, Israel, and the Sackler Faculty of Medicine, Tel-Aviv                         University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"David","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petah                         Tiqva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,7,1]]},"reference":[{"key":"atypb1","first-page":"416","volume":"71","author":"Stephansson EA","year":"1991","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000246547"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680160083009"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/096120330000900712"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04442.x"},{"key":"atypb6","first-page":"694","volume":"28","author":"Samarkos M","year":"2001","journal-title":"J Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203303lu403oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203303lu403oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T14:12:59Z","timestamp":1740838379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0961203303lu403oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1191\/0961203303lu403oa"],"URL":"https:\/\/doi.org\/10.1191\/0961203303lu403oa","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}