{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:45:08Z","timestamp":1780472708233,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p> The presence of antiphospholipid (aPL) antibodies and antiphospholipid syndrome (APS) was researchedin 57 childrenand adolescentswith systemic lupus erythematosus(SLE). The frequencyof aPL antibodies was 75.4% (anticardiolipin70.2% and lupus anticoagulant29.1%). The positivity for these antibodies fluctuated during the course of the disease. No association was found between aPL antibodiesand clinical or laboratory manifestationsor the autoantibodiesstudied, nor with the activity or gravity of the SLE. APS was diagnosed in 14% of the cases (eight patients), on average three years after the diagnosis of SLE. Four patients had arterial thrombosis (stroke, three; transient ischaemic attack, one; amaurosis fugax, two; renal, one), one presented with deep vein thrombosis (DVT) and three had involvement of small calibre vessels (osteonecrosis, two; transverse myelitis, one). Recurrences were observed in three of the eight cases (37.5%), with a mean interval of 13 months between the events. The presence of APS was associated with haemolytic anaemia, leukopenia, thrombocytopenia, coagulation abnormalities, ischaemic cerebrovascularaccidents, amaurosis fugax, osteonecrosisand interstitial pneumonitis. A negative association was observed between APS and the presence of anti-Ro antibodies. <\/jats:p>","DOI":"10.1191\/0961203303lu471oa","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"820-826","source":"Crossref","is-referenced-by-count":75,"title":["Antiphospholipid antibodies and antiphospholipid syndrome in 57 children and                 adolescents with systemic lupus erythematosus"],"prefix":"10.1177","volume":"12","author":[{"given":"L MA","family":"Campos","sequence":"first","affiliation":[{"name":"Paediatric Rheumatology Unit of the Children\u2019s Institute,                         Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical                         School, S\u00e3o Paulo, Brazil,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Kiss","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9 A","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Haematology Unit of Hospital das Cl\u00ednicas, University of                         S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A Almeida","family":"Silva","sequence":"additional","affiliation":[{"name":"Paediatric Rheumatology Unit of the Children\u2019s Institute,                         Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical                         School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"atypb1","first-page":"3","volume-title":"The Antiphospholipid Syndrome","author":"Asherson RA","year":"1996"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0889-857X(21)00057-0","volume":"20","author":"Petri MA.","year":"1994","journal-title":"Rheum Dis Clin North Ann"},{"key":"atypb3","first-page":"1321","volume":"20","author":"Ordi J","year":"1993","journal-title":"J Rheumatol"},{"key":"atypb4","first-page":"3","volume-title":"Annual Scientific Meeting of the American College of Rheumatology, 57, San Antonio, 1993. 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