{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:04:11Z","timestamp":1761609851700,"version":"3.38.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p> Within two years of the recognitionof autoantibodiesto ribosomal P proteinsin patients with systemic lupus erythematosus(SLE) an associationwith anti-P autoantibodieswith psychosiswas noted. While there has been some controversy about this association, ample evidence suggests a meaningful relationship between anti-P antibodies and central nervous system (CNS) disease. This evidence consists of 1) seven independent studies showing a strong relationship between anti-P antibodies and CNS disease; 2) longitudinal studies showing fluctuations of anti-P antibodies with episodes of psychosis; 3) correlation of anti-P antibodies with general disease activity; and 4) acid eluates form lupus renal tissuewere foundto contain anti-Pantibodiesenriched30-fold with respectto their specific activity in serum heralding a direct role of anti-P antibodies in disease expression. Finally, there is evidencethat the P protein resides on normal cells in an immunologicallyaccessibleway and evidence exists that anti-P antibodies are able to bind and penerate cells in culture, and once inside cells can affect a profound inhibition of protein synthesis in living cells. Taken together, these observations provide evidence linking anti-P antibodies to various forms of CNS disease. While this is true, there are other autoantibodiesin SLE patients such as anti-dsDNA and antiglialfibrillary protein which may also play a role in the CNS disease of SLE patients. Continued study will inform us of the relative contribution of these autoantibodies to CNS disease in SLE patients. <\/jats:p>","DOI":"10.1191\/0961203303lu502oa","type":"journal-article","created":{"date-parts":[[2004,1,6]],"date-time":"2004-01-06T23:57:29Z","timestamp":1073433449000},"page":"916-918","source":"Crossref","is-referenced-by-count":44,"title":["Ribosomal P antibodies and CNS lupus"],"prefix":"10.1177","volume":"12","author":[{"given":"M","family":"Reichlin","sequence":"first","affiliation":[{"name":"Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.2.459"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290806"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707303170503"},{"key":"atypb4","first-page":"1026","volume":"18","author":"Van Dam A","year":"1991","journal-title":"J Rheumatol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.4.489"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.10.779"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.9.1053"},{"key":"atypb8","first-page":"1681","volume":"18","author":"Sato T","year":"1991","journal-title":"J Rheumatol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.2.99"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199810)41:10<1819::AID-ART14>3.0.CO;2-Y"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90506-S"},{"key":"atypb12","first-page":"1681","volume":"2","author":"Yoshio T","year":"1995","journal-title":"J Rheumatol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199912)42:12<2728::AID-ANR34>3.0.CO;2-M"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500106"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115707"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4049\/jimmunol.159.4.2033","volume":"159","author":"Koscec M","year":"1997","journal-title":"J Immunol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4541"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.4049\/jimmunol.154.9.4857","volume":"154","author":"Koren E","year":"1995","journal-title":"J Immunol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1038\/nm1101-1189"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828695"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203303lu502oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203303lu502oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:43:35Z","timestamp":1740750215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0961203303lu502oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1191\/0961203303lu502oa"],"URL":"https:\/\/doi.org\/10.1191\/0961203303lu502oa","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"type":"print","value":"0961-2033"},{"type":"electronic","value":"1477-0962"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}