{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:23:06Z","timestamp":1778923386886,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p> Antiphospholipid (aPL) antibodies entailing anticardiolipin (aCL) and anti-\u03b2<jats:sub>2<\/jats:sub> glycoprotein I (anti-\u03b2<jats:sub>2<\/jats:sub> GPI) antibodies may be involved in a number of vascular diseases including coronary artery diseases (CAD) or stroke. Here we assessed the presence of aPL antibodies in acute coronary syndrome (ACS). The frequency of anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies was significantly higher (14.4%) in ACS in comparison to control healthy subjects (2%). In addition, serum concentrations of anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies were also increased in ACS. Anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies of the IgA isotype might be the most relevant for the onset and outcome of ACS. Regarding subclasses of ACS, anti-\u03b2<jats:sub>2<\/jats:sub> GPI IgA antibodies were elevated in unstable angina (UA) and myocardial infarction with ST elevation (STEMI), but not in myocardial infarction without ST elevation (NSTEMI). The involvement of anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies in ACS was more pronounced in men than women, and in younger rather than older patients. Finally, anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies in ACS were associated with previous stroke, but not with hypertension or previous myocardial infarction. Thus, anti-\u03b2<jats:sub>2<\/jats:sub> GPI antibodies may be involved in the thrombotic events underlying ACS. <\/jats:p>","DOI":"10.1191\/0961203304lu1011oa","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T21:58:52Z","timestamp":1088459932000},"page":"423-427","source":"Crossref","is-referenced-by-count":64,"title":["Antiphospholipid antibodies in acute coronary syndrome"],"prefix":"10.1177","volume":"13","author":[{"given":"K","family":"Veres","sequence":"first","affiliation":[{"name":"Intensive Care Unit, 3rd Department of Internal Medicine, University of                         Debrecen Medical Center, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lakos","sequence":"additional","affiliation":[{"name":"Regional Immunological Laboratory, 3rd Department of Internal Medicine,                         University of Debrecen Medical Center, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ker\u00e9nyi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Molecular Pathology, University                         of Debrecen Medical Center, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Szekanecz","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, 3rd Department of Internal Medicine, University                         of Debrecen Medical Center, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Divisions of Clinical Immunology, 3rd Department of Internal Medicine,                         University of Debrecen Medical Center, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Department of Medicine \u201cB\u201d, Chaim Sheba Medical                         Center, Tel-Hashomer, and the Sacker faculty of Medicine, Tel-Aviv                         University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Solt\u00e9sz","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, 3rd Department of Internal Medicine, University of                         Debrecen Medical Center, Debrecen, Hungary,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994935"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200105000-00009"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198911000-00004"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu339oa"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.3109\/08916939908994766"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0288"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2227"},{"key":"atypb8","first-page":"37","volume":"32","author":"Shoenfeld Y","year":"2000","journal-title":"Ann 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