{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:45:12Z","timestamp":1790729112415,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p> Scarring alopecia is a very frequent feature of chronic discoid lupus erythematosus (DLE). So far in the literature, only clinic-pathologic features or histopathologic-immunopathologic traits of DLE scarring alopecia (DLESA) have been reported. We describe the most significant features of clinical morphology, histopathology, serum and tissue immunopathology of 36 DLESA patients (41.9% of all our scarring alopecia patients). Clinically, 33.3% presented a single lesion and 52.7% presented multiple lesions of scarring alopecia, while 13.8% exhibited a picture resembling Pseudopelade of Brocq, with the classic \u2018footprints in the snow\u2019 appearance. The most frequent morphologic features were sclero-atrophy (80.5%) and erythema (63.8%). The main histopathologic aspects appeared to be fibrosis (100%), follicular hyperkeratosis (91.4%), epidermal atrophy (88.5%), lymphocytic infiltrate (88.5%), thickened basement membrane (77.1%) and basal vacuolar degeneration (74.2%). Antinuclear antibodies were present in 42.8% of patients and antigastric mucosa, antithyroid and anticardiolipin antibodies in 17-21% of patients. A positive lupus band test was demonstrated in 81.8% of cases and perivascular deposit in 30.3% of patients. Histopathology alone allowed a correct diagnosis only in 68.5% of cases; in the other cases, the diagnosis was assessed also taking into account immunopathologic findings. Our study defines the clinic, histopathologic and immunopathologic features of DLESA patients and points out that a multiparametric approach is mandatory to assess the diagnosis of DLESA. <\/jats:p>","DOI":"10.1191\/0961203304lu1041oa","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T21:58:52Z","timestamp":1088459932000},"page":"455-462","source":"Crossref","is-referenced-by-count":45,"title":["Scarring alopecia in discoid lupus erythematosus: a clinical, histopathologic                 and immunopathologic study"],"prefix":"10.1177","volume":"13","author":[{"given":"P","family":"Fabbri","sequence":"first","affiliation":[{"name":"Second Dermatology Clinic, Department of Dermatological Sciences,                         University of Florence, Florence, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Amato","sequence":"additional","affiliation":[{"name":"Second Dermatology Clinic, Department of Dermatological Sciences,                         University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Chiarini","sequence":"additional","affiliation":[{"name":"Second Dermatology Clinic, Department of Dermatological Sciences,                         University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Moretti","sequence":"additional","affiliation":[{"name":"Second Dermatology Clinic, Department of Dermatological Sciences,                         University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Massi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology and Oncology, University of Florence,                         Florence, 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