{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:45:59Z","timestamp":1783352759818,"version":"3.54.6"},"reference-count":52,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p> Hyperprolactinemia without clinical manifestations has been reported in some patients with systemic lupus erythematosus (SLE) because an increase of prolactin (PRL) is produced due to the BIG\/BIG molecular variant (molecular variant, 150 kD). This research project aimed to determine levels of PRL: its bioactive form, the little nonglycosylated form (NGPRL) and variants with decreased bioactivity such as the BIG\/BIG and the little glycosylated (GPRL), in 29 women and five men with SLE. PRL was assayed by IRMA with a kit from Immunotech Laboratory, the BIG\/BIG form by precipitation with polyethyleneglycol 6000, and the NGPRL and GPRL by chromatography on Concanavalin-A-Sepharose. Increased PRL was detected in seven patients (20.6%) of whom three had increased BIG\/BIG, six had increased GPRL and only four had increased NGPRL. The three cases with increased BIG\/BIG were contrasted by chromatography on Sephadex G-100. No increased PRL or any of the other variants assayed were found in men. Results were similar when PRL was evaluated in the same blood samples by a different IRMA (DPC Laboratory). The etiology of the hyperprolactinemia in some of these patients is unknown, but their lack of symptoms (galactorrhea or amenorrhea) could be due to the BIG\/BIG forms and basically to the glycosylation of the hormone. As for the relation between PRL and SLE activity, we found that hyperprolactinemic patients were younger, had a shorter history of illness, although it was not statistically significant, and a higher SLEDAI score. This would indicate a relation between hyperprolactinemia and lupus activity. The patients with increased BIG\/BIG form also had a very active illness at the time of the study. <\/jats:p>","DOI":"10.1191\/0961203304lu1068oa","type":"journal-article","created":{"date-parts":[[2004,8,21]],"date-time":"2004-08-21T01:09:48Z","timestamp":1093050588000},"page":"575-583","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of molecular heterogeneity of prolactin in human systemic lupus erythematosus"],"prefix":"10.1177","volume":"13","author":[{"given":"M","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Reumatolog\u00eca del Hospital San Mart\u00edn,                         Universidad Nacional de La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Colombani-Vidal","sequence":"additional","affiliation":[{"name":"Instituto de An\u00e1lisis Bioqu\u00edmicos de                         Endocrinolog\u00eda, La Plata, Buenos Aires, 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