{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:53:38Z","timestamp":1767653618660,"version":"3.48.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>The objective of this study was to assess child chloroquine ototoxicity after its use                 during the gestational period in systemic lupus erythematosus (SLE). Nineteen                 children over four years old were evaluated: nine were exposed to chloroquine                 diphosphate (CDP) during gestation and 10 were born from mothers that did not take                 this drug before conception or anytime during pregnancy (CONTROL). Pure tone                 audiometry was performed in all children and high and low frequency threshold means                 were compared to evaluate the hearing status. All nine mothers taking CDP were                 exposed to this drug at least during the first trimester of pregnancy (56% during                 the whole gestational period) and the mean time of CDP use was 6.1 + 2.9 months. No                 significant difference was found in children of CDP and CONTROL groups regarding age                 (7.6 + 4.4 versus 12.3 + 7.2 years; P 0.10, respectively) and gender (P 0.65). Pure                 tone high frequency thresholds, which are the first to be affected by ototoxic                 drugs, presented within normal limits in children exposed or not to CDP (8.5 + 5.0                 versus 7.4 + 3.6 dBHL; P 0.55, respectively). Likewise, the mean hearing thresholds                 at low frequencies were also similar in both groups (11.4 + 4.5 versus 11.9 + 3.0                 dBHL; P 0.66). In conclusion, child in utero exposure to chloroquine diphosphate                 does not seem to induce hearing impairment as measured by pure tone audiometry,                 reinforcing its safe use during pregnancy of lupus patients.<\/jats:p>","DOI":"10.1191\/0961203304lu528oa","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T18:25:36Z","timestamp":1083003936000},"page":"223-227","source":"Crossref","is-referenced-by-count":30,"title":["Chloroquine gestational use in systemic lupus erythematosus: assessing the                 risk of child ototoxicity by pure tone audiometry"],"prefix":"10.1177","volume":"13","author":[{"given":"E F","family":"Borba","sequence":"first","affiliation":[{"name":"Rheumatology Division, University of S\u00e3o Paulo, S\u00e3o                         Paulo, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Turrini-Filho","sequence":"additional","affiliation":[{"name":"Rheumatology Division, University of S\u00e3o Paulo, S\u00e3o                         Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K AM","family":"Kuruma","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Division, University of S\u00e3o Paulo,                         S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bertola","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Division, University of S\u00e3o Paulo,                         S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M EB","family":"Pedalini","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Division, University of S\u00e3o Paulo,                         S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Division, University of S\u00e3o Paulo,                         S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Bonf\u00e1","sequence":"additional","affiliation":[{"name":"Rheumatology Division, University of S\u00e3o Paulo, S\u00e3o                         Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.10.582"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.799"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678646092"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90363-4"},{"key":"e_1_2_1_5_1","first-page":"323","article-title":"The efficacy of antimalarials in systemic lupus erythematosus","volume":"2","author":"Rudnicki RD","year":"1975","unstructured":"Rudnicki RD , Gresham GE , Rothfield NF. 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