{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:06:58Z","timestamp":1789384018792,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> The objective of this study was to assess the prevalence, clinical, histological and immunological characteristics, and the long-term outcome of polymyositis-(PM) and dermatomyositis-(DM) associated lung disease, and to define subgroups of lung-associated inflammatory myopathies. This retrospective study included 81 consecutive patients diagnosed with PM\/DM. Pulmonary involvement was systematically investigated in relation to clinical symptoms by chest radiography, high resolution computed tomography and pulmonary function testing. Anti-synthetase autoantibodies (ASA) were analysed by ELISAandconfirmedbyproteinandRNA immunoprecipitation methods. Statistical analyses were done with the Student t-test and Fisher exact test. Cumulative survival probabilities were estimated by the Kaplan-Meier method and Cox regression analysis. Fifty patients (61%) presented pulmonary involvement. Thirty-two (39%) had interstitial lung disease and five of them had devastating acute interstitial pneumonia with pneumomediastinum and an unfavorable prognosis. Histology showed diffuse alveolar damage in this subgroup and ASA were negative. Eighteen patients (22%) presented restrictive myopathic lung disease; in three of them respiratory muscles could not maintain ventilation. ASA were positive in 17 of the 50 patients (34%) and were significantly associated with interstitial lung disease (OR: 4.5 [95% CI: 1.3-15.3]), arthritis (OR: 6.0 [95% CI: 1.3-29.2]) and \u2018mechanic hands\u2019 (OR: 8.5 [95% CI: 1.7-41.4]); the presence of these autoantibodies did not imply worse survival prognosis. We concluded that clinical and immunological characteristics allowed the grouping of patients into different types of PM\/DM lung-associated disease. Presence of ASA did not affect survival. ASA-negative patients with acute interstitial pneumonitis and pneumomediastinum had an unfavorable prognosis. <\/jats:p>","DOI":"10.1191\/0961203305lu2158oa","type":"journal-article","created":{"date-parts":[[2005,7,16]],"date-time":"2005-07-16T12:30:14Z","timestamp":1121517014000},"page":"534-542","source":"Crossref","is-referenced-by-count":113,"title":["Polymyositis\/dermatomyositis-associated lung disease: analysis of a series of                 81 patients"],"prefix":"10.1177","volume":"14","author":[{"given":"A","family":"Selva-O\u2019Callaghan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Vall D\u2019Hebron General                         Hospital, Barcelona, Spain,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Labrador-Horrillo","sequence":"additional","affiliation":[{"name":"Autoimmunity Research Unit, Vall D\u2019Hebron General Hospital,                         Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Mu\u00f1oz-Gall","sequence":"additional","affiliation":[{"name":"Pneumology Service, Vall D\u2019Hebron General Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Mart\u00ednez-Gomez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, Vall D\u2019Hebron                         General Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Maj\u00f3-Masferrer","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Vall D\u2019Hebron General                         Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Solans-Laque","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vall D\u2019Hebron General                         Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Simeon-Aznar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vall D\u2019Hebron General                         Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Morell-Brotard","sequence":"additional","affiliation":[{"name":"Pneumology Service, Vall D\u2019Hebron General Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vilardell-Tarr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Vall D\u2019Hebron General                         Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200111000-00009"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0272-5231(05)70111-8","volume":"19","author":"Schwartz MI.","year":"1998","journal-title":"Clin Chest Med"},{"key":"atypb3","first-page":"260","volume":"189","author":"Selva A","year":"1991","journal-title":"Rev Clin Esp"},{"key":"atypb4","first-page":"521","volume":"112","author":"Mir\u00f3 O","year":"1999","journal-title":"Med Clin (Barc)"},{"key":"atypb5","first-page":"1336","volume":"25","author":"Marie I","year":"1998","journal-title":"J Rheumatol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.1.23"},{"key":"atypb7","first-page":"102","volume":"14","author":"Takizawa H","year":"1987","journal-title":"J Rheumatol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200011000-00005"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2103110"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/art.10794"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.041s1693"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102987"},{"key":"atypb14","first-page":"217","volume":"22","author":"Roca J","year":"1986","journal-title":"Bull Eur Physiopathol Respir"},{"key":"atypb15","first-page":"696","volume":"99","author":"Black LF","year":"1969","journal-title":"Am Respir Dis"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.4049\/jimmunol.162.4.2315","volume":"162","author":"Hirakata M","year":"1999","journal-title":"J Immunol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/art.10435"},{"key":"atypb18","first-page":"104","volume":"12","author":"Martin L","year":"1985","journal-title":"J Rheumatol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.8.914"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh226"},{"key":"atypb21","first-page":"1921","volume":"23","author":"Grau JM","year":"1996","journal-title":"J Rheumatol"},{"key":"atypb22","first-page":"663","volume":"11","author":"Hochberg MC","year":"1984","journal-title":"J Rheumatol"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.4.2.236-240.1997"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.50012"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/s100670070030"},{"key":"atypb26","first-page":"733","volume":"16","author":"Jansen TL","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1080\/03009749950155805"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.4.476"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200104"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.2.141"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1002\/art.11090"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1159\/000070852"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh285"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh079"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh062"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1007\/s100670070027"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01927-3"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709065660"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1215::AID-ART11>3.0.CO;2-Y"},{"key":"atypb40","first-page":"298","volume":"29","author":"Pakas I","year":"2002","journal-title":"J Rheumatol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203305lu2158oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203305lu2158oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T15:22:31Z","timestamp":1741015351000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0961203305lu2158oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1191\/0961203305lu2158oa"],"URL":"https:\/\/doi.org\/10.1191\/0961203305lu2158oa","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}