{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:32Z","timestamp":1761742652592,"version":"3.38.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p> Renal biopsies of 69 patients with lupus nephritis were studied according to the WHO classification. The aim of the present study was to correlate the interstitial tryptase-positive mast cells with the interstitial TGF-\u03b21 and \u03b1-SM actin expression and clinical outcome of lupus nephritis, and identify the pathological role of the interstitial tryptase-positive mast cells in lupus nephritis. The mean follow-up time was 70.7 \u00b1 54.4 months. Eight patients were grouped as WHO class II lupus nephritis, 15 patients as class III, 28 patients as class IV and 18 patients as class V. Interstitial tryptase-positive mast cells were not correlated with clinical outcome and interstitial TGF-\u03b21 expression in lupus nephritis. Interstitial tryptase-positive mast cells were correlated with tubulo-interstitial \u03b1-SM actin expression for WHO class V lupus nephritis, but not to the other classes. In conclusion, in spite of interstitial tryptase-positive mast cells being related to renal interstitial fibrosis process, their expression according to the clinical outcome of lupus nephritis was not significant. <\/jats:p>","DOI":"10.1191\/0961203305lu2188oa","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T21:02:19Z","timestamp":1129842139000},"page":"814-821","source":"Crossref","is-referenced-by-count":10,"title":["Mast cells, TGF-\u03b21 and myofibroblasts expression in lupus nephritis outcome"],"prefix":"10.1177","volume":"14","author":[{"given":"R Cuan","family":"Ravinal","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine of Ribeir\u00e3o Preto,                         University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine of Ribeir\u00e3o Preto,                         University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine of Ribeir\u00e3o                         Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dantas","sequence":"additional","affiliation":[{"name":"Division of Nephrology, School of Medicine of Ribeir\u00e3o Preto,                         University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Faculty of Medicine of                         Tri\u00e2ngulo Mineiro, Uberaba, 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