{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:21:10Z","timestamp":1767666070905,"version":"3.38.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p> The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of the disease; 3) cross reacting antibodies between the pathogen and self molecules; 4) endothelial cell activation in the \u2018crime-area\u2019 i.e., the valves; 5) some of the patients with RF have circulating antiphospholipid antibodies, while APS may be associated with streptococcal infection; and 6) recently, a cross-reactivity between antibodies directed to the streptococcal M-protein and its synthetic derivative in rheumatic fever (RF) and antibodies derived from APS patients targeting the beta-2-glycoprotein-I (\u03b22GPI) and a \u03b22GPI related synthetic peptide. In the current paper, we summarize the possible links between the heart involvement in RF and APS. <\/jats:p>","DOI":"10.1191\/0961203305lu2203oa","type":"journal-article","created":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T21:13:40Z","timestamp":1127423620000},"page":"697-701","source":"Crossref","is-referenced-by-count":12,"title":["From rheumatic fever to Libman-Sacks endocarditis: is there any possible                 pathogenetic link?"],"prefix":"10.1177","volume":"14","author":[{"given":"M","family":"Blank","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B and The Center for Autoimmune Diseases,                         Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv                         University, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Aron-Maor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B and The Center for Autoimmune Diseases,                         Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv                         University, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B and The Center for Autoimmune Diseases,                         Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv                         University, Israel, Incumbent of the Laura Schwarz-Kipp Chair for Research                         of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University,                         Israel,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"atypb1","first-page":"1799","volume-title":"Principles and practice of infectious diseases","author":"Bisno 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