{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:26Z","timestamp":1761540686947,"version":"3.38.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p> \u03b22<jats:sub>2<\/jats:sub>-glycoprotein I (\u03b22GPI) is a plasma protein suspected to have a role in inhibition of thrombosis. This suspicion is reinforced by the observation that \u03b22GPI is the major target for autoantibodies in the antiphospholipid syndrome. However, little is known about its circulating levels in common thrombotic diseases or inflammation. We measured \u03b22GPI levels in 344 healthy controls, 58 normal pregnancies, 102 patients with non-haemorrhagic stroke, 121 patients with acute coronary syndrome and 200 patients with elevated C-reactive protein (CRP). In healthy individuals, we found a strong positive correlation between age and \u03b22GPI concentration ( r = 0.274, P &lt; 0.001) and that \u03b22GPI levels fall significantly after the eighth week of pregnancy ( P = 0.002). We also found significantly reduced levels of \u03b22GPI in patients with stroke and in elderly patients with myocardial syndrome ( P = 0.013 and 0.043). However, in neither group did \u03b22GPI levels change in the following six months, suggesting that the reduced levels were not a transient post-event phenomenon. In patients with inflammation, \u03b22GPI levels showed a significant negative correlation with CRP ( r =-0.284, P &lt; 0.001) and positively correlated with albumin and transferrin ( r = 0.372 and 0.453, respectively with P &lt; 0.001 for both). Furthermore, the largest reduction in \u03b22GPI levels occurred in patients with the highest CRP values ( P &lt; 0.001). <\/jats:p>","DOI":"10.1191\/0961203306lu2270oa","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T21:26:18Z","timestamp":1140125178000},"page":"87-93","source":"Crossref","is-referenced-by-count":32,"title":["Circulating levels of \u03b22-glycoprotein I in thrombotic disorders and                 in inflammation"],"prefix":"10.1177","volume":"15","author":[{"given":"F","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Dublin Institute of Technology, St                         James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"White","sequence":"additional","affiliation":[{"name":"National Centre for Hereditary Coagulation Disorders, St                         James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Dublin Institute of Technology, St                         James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Feighery","sequence":"additional","affiliation":[{"name":"Department of Immunology, St James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Doyle","sequence":"additional","affiliation":[{"name":"Medicine for the Elderly, St James\u2019s Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beaumont Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Moroney","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beaumont Hospital, Dublin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Smith","sequence":"additional","affiliation":[{"name":"Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic                         of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic                         of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Keenan","sequence":"additional","affiliation":[{"name":"Trinity Smurfit Institute of Genetics, Trinity College Dublin; Republic                         of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Immunology, St James\u2019s Hospital, Dublin,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"atypb1","first-page":"29","volume-title":"The antiphospholipid syndrome","author":"Asherson RA","year":"1996"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(97)00063-6"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920532"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10362-8"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(83)90070-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(84)90168-X"},{"key":"atypb7","first-page":"179","volume":"13","author":"Del Papa N","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400304"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.4049\/jimmunol.160.11.5572","volume":"160","author":"Del Papa N","year":"1998","journal-title":"J Immunol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.9.900"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(80)90421-1"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657748"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.5.1255.1255"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1994.1024"},{"key":"atypb15","first-page":"550a","volume":"86","author":"Long M","year":"1995","journal-title":"Blood"},{"key":"atypb16","first-page":"610","volume":"80","author":"Harper MF","year":"1998","journal-title":"Thromb Haemost"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.5.1086.1086"},{"key":"atypb18","first-page":"519","volume":"111","author":"Henry ML","year":"1988","journal-title":"J Lab Clin Med"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(88)90065-1"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(88)90356-4"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653871"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14323.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90237-0"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649577"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90110-9"},{"key":"atypb26","first-page":"930","volume":"69","author":"Walker FJ.","year":"1993","journal-title":"Thromb Haemost"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600403"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614566"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.10.908"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650220"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648517"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.4.1594"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00236-3"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107001-00016"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012295"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00797-5"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1080\/003655102753517217"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90449-L"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1357"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(84)90152-0"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2003.11978046"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90136-C"},{"key":"atypb45","first-page":"294","volume":"5","author":"Cleve H.","year":"1968","journal-title":"Humangenetik"},{"key":"atypb46","first-page":"212","volume":"75","author":"Cohnen G.","year":"1970","journal-title":"J Lab Clin Med"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278835"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1177\/000456329102800315"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1177\/096120339200100305"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199906000-00006"},{"key":"atypb51","first-page":"63","volume":"105","author":"Mehdi H","year":"1999","journal-title":"Hum Genetics"},{"key":"atypb52","first-page":"454","volume-title":"Pathology","author":"Benditt EP","year":"1994"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.17.2227"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0288"},{"key":"atypb55","first-page":"314","volume":"3","author":"Matsuura E","year":"1994","journal-title":"Lupus"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.d01-948.x"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1159\/000299596"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661167"},{"key":"atypb59","first-page":"263","volume":"19","author":"Pinto S","year":"1988","journal-title":"Acta Eur Fertil"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb07630.x"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993903"},{"key":"atypb62","first-page":"99","volume-title":"Clinical physiology in obstetrics","author":"Letsky EA.","year":"1998"},{"key":"atypb63","first-page":"267","volume-title":"Medical disorders during pregnancy","author":"Letsky EA.","year":"2000"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1007\/BF00567007"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102755"},{"key":"atypb66","first-page":"286","volume-title":"Clinical physiology in obstetrics","author":"Baylis C","year":"1998"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203306lu2270oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203306lu2270oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T18:17:35Z","timestamp":1740680255000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0961203306lu2270oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1191\/0961203306lu2270oa"],"URL":"https:\/\/doi.org\/10.1191\/0961203306lu2270oa","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"type":"print","value":"0961-2033"},{"type":"electronic","value":"1477-0962"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}