{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:31:34Z","timestamp":1775025094916,"version":"3.50.1"},"reference-count":66,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p> Autoimmune diseases (AD) occur frequently in women during their childbearing years and may influence pregnancy outcome and neonatal health. Patients with systemic lupus erythematosus (SLE) can experience a disease flare-up during pregnancy with potential negative effects on the product of conceptus, especially if the disease is active. Recurrent pregnancy loss is now considered as a treatable clinical condition associated with the presence of circulating antiphospholipid antibodies (aPL). The neonatal lupus syndromes (NLS), caused by the transplacental passage of maternal IgG anti-Ro\/SS-A and anti-La\/SS-B antibodies to the fetus, carry significant morbidity and mortality in case of cardiac manifestations. Immunosuppressive agents are often administered during pregnancy in order to control maternal disease and to ensure a better pregnancy outcome. Nowadays, owing to our increasing knowledge of the disease pathophysiological mechanisms and the development of combined medical-obstetric clinics, pregnancy outcome in patients with AD has notably improved. <\/jats:p>","DOI":"10.1191\/0961203306lu2279rr","type":"journal-article","created":{"date-parts":[[2006,3,19]],"date-time":"2006-03-19T21:22:59Z","timestamp":1142803379000},"page":"156-160","source":"Crossref","is-referenced-by-count":38,"title":["Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome)"],"prefix":"10.1177","volume":"15","author":[{"given":"A","family":"Tincani","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology, Brescia Hospital and University,                         Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bompane","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University of Rome, \u201cLa                         Sapienza\u201d, 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