{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:49:51Z","timestamp":1789181391455,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p> Antiphospholipid syndrome (APS) is a clinical entity characterized by arterial and venous thrombosis, adverse obstetric outcome and the presence of antibodies against phospholipids in serum or plasma. The objective of the present study is to describe a rare case of APS that occurred in a neonate born from a patient previously diagnosed as primary APS. A male, preterm born twin infant, whose mother had been diagnosed as primary APS, developed thrombocytopenia, livedo reticularis, pericardial effusion and thrombosis of the left subclavian and external jugular veins concomitantly with severe respiratory tract infection soon after his delivery, that culminated with his death two months after the birth, in spite of the large spectrum antibiotic therapy and all supportive measures. Laboratory findings included high titers of IgM anticardiolipin antibodies and moderate titers of IgG isotype and negative antinuclear antibody, configuring a case of neonatal APS. Neonatal APS is a rare clinical condition, with only a few cases described in the literature. Its occurrence may depend on the passage of antibodies through the placenta or, as it seems to have occurred in the present case, by the production of de novo antibodies by the fetus. The present case illustrates the necessity of a higher surveillance of the neonates born from mothers with primary APS or systemic lupus erythematosus (SLE) for the eventual development of such complication. <\/jats:p>","DOI":"10.1191\/0961203306lu2295cr","type":"journal-article","created":{"date-parts":[[2006,4,30]],"date-time":"2006-04-30T23:17:11Z","timestamp":1146439031000},"page":"301-303","source":"Crossref","is-referenced-by-count":30,"title":["Neonatal antiphospholipid syndrome"],"prefix":"10.1177","volume":"15","author":[{"given":"A M Soares","family":"Rolim","sequence":"first","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica do Itaigara, Hospital da                         Crian\u00e7a-Obras Sociais Irm\u00e3 Dulce and Universidade                         Federal da Bahia, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Castro","sequence":"additional","affiliation":[{"name":"Hospital Santa Izabel (HSI), Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Santiago","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica and                         Servi\u00e7o de Reumatologia do HSI, Bahia, Brazil,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81730-5"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","volume":"96","author":"Schmidt B","year":"1995","journal-title":"Pediatrics"},{"key":"atypb3","first-page":"724","volume":"78","author":"Roy M","year":"1997","journal-title":"Thromb Haemost"},{"key":"atypb4","first-page":"66","volume":"14","author":"Tabbutt S","year":"1994","journal-title":"J Perinatol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1089oa"},{"key":"atypb7","first-page":"1183","volume-title":"Neonetalperinatal medicine: Diseases of the fetus and infant","author":"Luchtman-Jones L","year":"2002"},{"key":"atypb8","first-page":"528","volume":"68","author":"El-Roeiy A","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200405"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203306lu2295cr","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/0961203306lu2295cr","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T14:33:42Z","timestamp":1740839622000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/0961203306lu2295cr"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1191\/0961203306lu2295cr"],"URL":"https:\/\/doi.org\/10.1191\/0961203306lu2295cr","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}