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Therefore, the aim of study was to evaluate the influence of seven-month chloroquine                 treatment with a 250 mg daily dose on arrhythmia, conduction disturbances as well as                 heart rate variability and repolarization parameters assessed in 24-hour Holter                 monitoring. The studied group included 28 SLE patients treated with chloroquine as a                 monotherapy. In all the patients standard 12 leads surface ECG (50 mm) and the                 24-hour ECG Holter monitoring (Oxford Medilog Excel-2) were performed before and                 after chloroquine phosphate treatment. All subjects presented sinus rhythm both at                 the enrollment and after treatment. No episodes of paroxysmal arrhythmias or                 conduction disturbances were reported during the study. All the patients were                 characterized by tendency to tachycardia, but no significant differences in mean                 heart rate were found before and after chloroquine administration. Similarly, no                 changes in heart rate variability or repolarization parameters were observed.<\/jats:p>","DOI":"10.1191\/0961203306lu2345oa","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T19:46:42Z","timestamp":1154634402000},"page":"521-525","source":"Crossref","is-referenced-by-count":49,"title":["The Cardiac Safety of Chloroquine Phosphate Treatment in Patients with                 Systemic Lupus Erythematosus: The Influence on Arrhythmia, Heart Rate Variability                 and Repolarization Parameters"],"prefix":"10.1177","volume":"15","author":[{"given":"A","family":"Wozniacka","sequence":"first","affiliation":[{"name":"Department of Dermatology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Cygankiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Chudzik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sysa-J\u0119drzejowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JK","family":"Wranicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,8]]},"reference":[{"key":"e_1_2_1_1_1","first-page":"395","article-title":"Pharmakinetics of antimalarials and proposals for dosage regiments","volume":"16","author":"Ritschel WA","year":"1978","unstructured":"Ritschel WA , Hammer GV , Thompson GA. 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