{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:04:08Z","timestamp":1761609848859,"version":"3.38.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p> The objective of this study was to assess the impact of murine recombinant IFN-\u03b3 and anti-IFN-\u03b3 monoclonal antibody on the BALB\/c mice experimental model of lupus. BALB\/c female mice were immunized with a human anti-DNA antibody that carries the 16=6 idiotype. These mice were divided into several therapeutic groups according to different treatment strategies; injection with mouse recombinant IFN-\u03b3, anti-IFN-\u03b3 mAb, phosphate-buffered saline (PBS), irrelevant mouse IgG and control groups that were neither treated nor immunized with the human anti-DNA antibody. <\/jats:p><jats:p> The administration of IFN-\u03b3 intensified the degree of clinical, histological and serological parameters in this model of BALB\/c murine lupus. This immunomanipulation decreased the mice longevity. All the laboratory parameters reflected acceleration of the disease in the IFN-\u03b3 treated group as an elevated sedimentation rate, decreased white blood cell count and the development of massive proteinuria. One month after the boost injection, all the mice that were immunized with the anti-DNA antibody, developed high titers of autoantibodies; however, following an additional month, their levels declined in the IFN-\u03b3 treated group. These findings were in concordance with an increased glomerular deposition of immune complexes in the IFN-\u03b3 treated mice. IFN-\u03b3 upregulated the levels of IL-4 and increased the number of IL-4 and IL-6 secreting splenocytes. <\/jats:p><jats:p> In conclusion IFN-\u03b3 administration can aggravate the clinical and laboratory outcome of 16=6id induced lupus in BALB\/c mice. <\/jats:p>","DOI":"10.1191\/096120398678920406","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"445-454","source":"Crossref","is-referenced-by-count":17,"title":["Immunomodulation of murine experimental SLE-like disease by interferon-\u03b3"],"prefix":"10.1177","volume":"7","author":[{"given":"H","family":"Amital","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Levi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Blank","sequence":"additional","affiliation":[{"name":"Research Unit of Autoimmune Diseases and the 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