{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:07:06Z","timestamp":1760044026591,"version":"3.38.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p> Neonatal lupus erythematosus (NLE), characterized by two major symptoms of congenital heart block (CHB) and transient cutaneous lesions, is an antibody mediated disorder due to placentally transmitted maternal autoantibodies to Ro\/SSA and\/or La\/SSB. We genotyped 14 mothers, 9 children with CHB, 8 with cutaneous NLE only and 5 asymptomatic siblings at HLA class I loci, by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) combined with sequence-specific amplification. Mothers of children with NLE exhibited a very high polymorphism of HLA class I genes. Significant increases of HLA-B*1501 (B62) and Cw*0303 (Cw9) with absence of HLA-Al\/B8 haplotype in Japanese mothers differed from the serologically defined HLA class I profiles among NLE mothers in white and North American black populations. Child\/mother heterozygous HLA-A\/B\/C haplotype identity, which extended to HLA-class II DR\/DQ loci, was observed in only one of 9 cases with CHB. No association was found between HLA class I alleles of children and the symptoms of NLE. These findings provide for the opportunity to investigate the primary genetic associations with NLE\/CHB in different ethnic groups. <\/jats:p>","DOI":"10.1191\/096120399678840891","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"751-754","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal lupus erythematosus: analysis of HLA class I genes in Japanese                 child\/mother pairs"],"prefix":"10.1177","volume":"8","author":[{"given":"S","family":"Miyagawa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Nara Medical University, Nara, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kidoguchi","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Osaka Medical Center and Research                         Institute for Maternal and Child Health, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kaneshige","sequence":"additional","affiliation":[{"name":"Shionogi Biomedical Laboratory, Diagnostic Science Department, Shionogi & Co, Ltd, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nara Medical University, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"doi-asserted-by":"publisher","key":"atypb1","DOI":"10.1016\/S0889-857X(05)70349-5"},{"doi-asserted-by":"publisher","key":"atypb2","DOI":"10.1016\/0896-8411(91)90015-5"},{"doi-asserted-by":"publisher","key":"atypb3","DOI":"10.1002\/art.1780400532"},{"doi-asserted-by":"publisher","key":"atypb4","DOI":"10.1191\/096120399678847407"},{"doi-asserted-by":"publisher","key":"atypb5","DOI":"10.1016\/0198-8859(92)90025-I"},{"doi-asserted-by":"publisher","key":"atypb6","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"doi-asserted-by":"publisher","key":"atypb7","DOI":"10.1111\/j.1399-0039.1997.tb02910.x"},{"doi-asserted-by":"publisher","key":"atypb8","DOI":"10.1111\/1523-1747.ep12292592"},{"doi-asserted-by":"publisher","key":"atypb9","DOI":"10.1016\/S0198-8859(97)00031-1"},{"doi-asserted-by":"publisher","key":"atypb10","DOI":"10.1111\/j.1399-0039.1998.tb03048.x"},{"doi-asserted-by":"publisher","key":"atypb11","DOI":"10.1111\/j.1399-0039.1994.tb02375.x"},{"doi-asserted-by":"publisher","key":"atypb12","DOI":"10.1111\/j.1399-0039.1996.tb02512.x"},{"doi-asserted-by":"publisher","key":"atypb13","DOI":"10.1097\/00005792-199203000-00003"},{"doi-asserted-by":"publisher","key":"atypb14","DOI":"10.7326\/0003-4819-99-5-592"},{"key":"atypb15","first-page":"533","volume":"22","author":"Brucato A","year":"1995","journal-title":"J Rheumatol"},{"doi-asserted-by":"publisher","key":"atypb16","DOI":"10.1191\/096120399678847399"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120399678840891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/096120399678840891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T07:33:32Z","timestamp":1740814412000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/096120399678840891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1191\/096120399678840891"],"URL":"https:\/\/doi.org\/10.1191\/096120399678840891","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"type":"print","value":"0961-2033"},{"type":"electronic","value":"1477-0962"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}