{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:53:10Z","timestamp":1780469590899,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p> Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading to third-degree atrioventricular block. However, some genetic or environmental factors may also be involved. We have searched for genetic markers that play a role in immune response and that would be pathognomonic for the disease, either in mothers by regulating their immune response or in children by affecting antigen presentation and target for the maternal immune response. We have compared HLA class I and II alleles of the children with their mother and with healthy individuals and searched for HLA markers that would be emphasized in children. We have shown that particular DQ alleles in the child predispose to CHB, perhaps serving as antigen-presenting molecules on site. In addition, the HLA-Cw3 allele is involved, although its function remains to be clarified. In our results, children with CHB were often identical to their mothers in alleles of DRB, DQA and DQB loci, thus affecting foetomaternal recognition and suggesting that cell-mediated mechanisms could be involved in the pathogenesis. <\/jats:p>","DOI":"10.1191\/096120399678847407","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"60-67","source":"Crossref","is-referenced-by-count":38,"title":["Role of HLA in congenital heart block: susceptibility alleles in children"],"prefix":"10.1177","volume":"8","author":[{"given":"M-K","family":"Sire","sequence":"first","affiliation":[{"name":"Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service,                         Helsinki, Finland: Marja-Kaisa Sire\u00e9n, Finnish Red Cross, Blood                         Transfusion Service, Kivihaantie 7, FIN-00310 Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Julkunen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Peijas Hospital, Vantaa, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kaaja","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Helsinki University Central                         Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ekblad","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70313-6"},{"issue":"9","key":"atypb2","first-page":"1263","volume":"36","author":"Buyon JP","year":"1993","journal-title":"Comparison of enzyme-linked immunosorbent assay and immunoblot for measurement of anti-SS-A\/Ro and anti-SS-B\/La antibodies"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6173.1235"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00811.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb14151.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400223"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198411000-00003"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1992.tb03212.x"},{"issue":"3","key":"atypb9","first-page":"541","volume":"22","author":"Brucato A","year":"1995","journal-title":"J Rheumatol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199203000-00003"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400532"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847399"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1996.tb02695.x"},{"key":"atypb14","unstructured":"Kimura A                 ,                      Sasazuki T                 . 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