{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:13:12Z","timestamp":1782299592531,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p> Introduction: Systemic lupus erythematosus (SLE) in children usually follows a more severe course than in adults, but sometimes in the previous studies reported there are many confounding factors <\/jats:p><jats:p> Objective: To analyse the immunological and clinical characteristics of SLE juvenile onset and SLE adult onset. <\/jats:p><jats:p> Methods: We studied 179 patients with SLE, 49 patients were aged 6 \u2013 18 yrs at onset of disease. Anti-dsDNA antibodies were detected by radioimmunoassay and antibodies to extractable nuclear antigens (ENA): anti-nRNP, anti-Sm, anti-Ro\/SS-A and anti-La\/SS-B antibodies by ELISA, counterimmuno-electrophoresis and immunoblotting. <\/jats:p><jats:p> Results: Juvenile-onset SLE shows a higher frequency of cutaneous vasculitis (44.8% vs 27.6%; P &lt; 0.05), seizures (18.3% vs 7.6%; P &lt; 0.05) nephropathy (67.3% vs 48.4%; P &lt; 0.025), and discoid lupus erythematosus (26.5% vs 13.8%; P &lt; 0.05). The incidence of articular manifestations is lower than in adults (85.7% vs 96.1%; P &lt; 0.025). No significant differences were found between the two groups in relation with the prevalence of antinuclear antibodies. <\/jats:p><jats:p> Conclusions: Juvenile-onset SLE has more frequent neurological and renal manifestations than adult-onset SLE, but immunological markers are similar in both groups. These features suggest the most severe clinical manifestations in the juvenile-onset SLE group are not related with the presence of studied antibodies by different methods. <\/jats:p>","DOI":"10.1191\/096120399678847786","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"287-292","source":"Crossref","is-referenced-by-count":125,"title":["Immunological and clinical differences between juvenile and adult onset of                 systemic lupus erythematosus"],"prefix":"10.1177","volume":"8","author":[{"given":"L","family":"Carre\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J","family":"L\u00f3pez-Longo","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Service of Immunology \u2018Gregorio                         Mara\u00f1\u00f3n\u2019 Hospital, Universidad Complutense of                         Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Monteagudo","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Service of Immunology \u2018Gregorio                         Mara\u00f1\u00f3n\u2019 Hospital, Universidad Complutense of                         Madrid, Spain; Servicio de Reumatolog\u00eda, Hospital                         General Universitario `Gregorio Mara\u00f1\u00f3n', c\/o Dr                         Esquerdo 46, 28007 Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rodr\u00edguez-Mahou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bascones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Service of Immunology \u2018Gregorio                         Mara\u00f1\u00f3n\u2019 Hospital, Universidad Complutense of                         Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Saint-Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lapointe","sequence":"additional","affiliation":[{"name":"Service of Immunology, Rheumatology and Allergology, `Ste Justine'                         Hospital, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1542\/peds.42.1.37","volume":"42","author":"Meislin AG","year":"1968","journal-title":"Pediatrics"},{"key":"atypb2","first-page":"287","volume":"20","author":"King KK","year":"1977","journal-title":"Arthritis 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