{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:47:50Z","timestamp":1785610070993,"version":"3.56.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p> B ackground and aim: C onversion to multiple sclerosis (MS) after optic neuritis and myelitis has been thoroughly studied; however, limited data are available regarding conversion to MS after a clinically isolated syndrome of the brainstem (CISB). The aim of this study was to investigate conversion to MS in patients with C ISB. Methods: Fifty-one patients with C ISB were prospectively studied. C ranial magnetic resonance imaging (MRI), determination of oligoclonal bands (OBs) in the cerebrospinal fluid (C SF) and evoked potentials (EPs) were performed. Based on conversion to MS at follow-up, the sensitivity, specificity, accuracy and positive and negative predictive values of these tests were calculated. Results: C linically definite MS developed in 18 (35%) patients after a mean follow-up of 37 months. Paty\u2019s MRI criteria showed a sensitivity of 89%, a specificity of 52% and an accuracy of 65%; Fazekas\u2019 criteria showed a sensitivity of 89%, a specificity of 48% and an accuracy of 63%; Barkhof\u2019s criteria showed a sensitivity of 78%, a specificity of 61% and an accuracy of 67%. The presence of O Bs in the C SF showed a sensitivity of 100%, a specificity of 42% and an accuracy of 63%. No differences for neurophysiological parameters were found between patients who did and those who did not convert to MS. C onclusion: Fulfilling Paty\u2019s, Fazekas\u2019 or Barkhof\u2019s MRI criteria and the presence of O Bs in the C SF are associated with a higher risk of conversion to MS in patients with C ISB. Determinatio n of O Bs in the C SF has the greatest sensitivity of all tests. Barkhof\u2019s MRI criteria have greater specificity (although less than previously published for mixed cohorts of clinically isolated syndromes) in predicting conversion to MS for C ISB than either Paty\u2019s or Fazekas\u2019 criteria. <\/jats:p>","DOI":"10.1191\/1352458503ms847oa","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"39-43","source":"Crossref","is-referenced-by-count":46,"title":["C onversion to multiple sclerosis after a clinically isolated syndrome of the                 brainstem: cranial magnetic resonance imaging, cerebrospinal fl uid and                 neurophysiological findings"],"prefix":"10.1177","volume":"9","author":[{"given":"J","family":"Sastre-Garriga","sequence":"first","affiliation":[{"name":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a;,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tintor\u00e9","sequence":"additional","affiliation":[{"name":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rovira","sequence":"additional","affiliation":[{"name":"Unitat de Resson\u00e0ncia Magne`tica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Griv\u00e9","sequence":"additional","affiliation":[{"name":"Unitat de Resson\u00e0ncia Magne`tica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Pericot","sequence":"additional","affiliation":[{"name":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Comabella","sequence":"additional","affiliation":[{"name":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Thompson","sequence":"additional","affiliation":[{"name":"Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Montalban","sequence":"additional","affiliation":[{"name":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Vall                         d\u2019Hebron, Barcelona, Espa\u00f1a;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.3.495"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260508"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410315"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.5.572"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1720"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.180"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.12.1822"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"atypb9","first-page":"702","volume":"21","author":"Tintor\u00e9 M","year":"2000","journal-title":"Am J 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