{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:12:13Z","timestamp":1791911533105,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p> Using multivariate analyses, individual risk of clinically definite multiple sclerosis (C DMS) after monosymptomatic optic neuritis (MO N) was quantified in a prospective study with clinical MO N onset during 1990 -95 in Stockholm, Sweden. During a mean follow-up time of 3.8 years, the presence of MS-like brain magnetic resonance imaging (MRI) lesions and oligoclonal immunoglobulin (Ig) G bands in cerebrospinal fluid (CSF) were strong prognostic markers of C DMS, with relative hazard ratios of 4.68 {95% confidence interval (CI) 2.21 -9.91} and 5.39 (95% C I 1.56 -18.61), respectively. Age and season of clinical onset were also significant predictors, with relative hazard ratios of 1.76 (95% C I 1.02 -3.04) and 2.21 (95% C I 1.13 -3.98), respectively. Based on the above two strong predicto rs, individual probability of C DMS development after MO N was calculated in a three-quarter sample drawn from a cohort, with completion of follow-up at three years. The highest probability, 0.66 (95% C I 0.48 -0.80), was obtained for individuals presenting with three or more brain MRI lesions and oligoclonal bands in the C SF, and the lowest, 0.09 (95% C I 0.02 -0.32), for those not presenting with these traits. Medium values, 0.29 (95% C I 0.13 -0.53) and 0.32 (95% C I 0.07 -0.73), were obtained for individuals discordant for the presence of brain MRI lesions and oligoclonal bands in the C SF. These predictions were validated in an external one-quarter sample. <\/jats:p>","DOI":"10.1191\/1352458503ms895oa","type":"journal-article","created":{"date-parts":[[2003,3,29]],"date-time":"2003-03-29T00:41:00Z","timestamp":1048898460000},"page":"135-141","source":"Crossref","is-referenced-by-count":24,"title":["Predicting multiple sclerosis at optic neuritis onset"],"prefix":"10.1177","volume":"9","author":[{"given":"Y P","family":"Jin","sequence":"first","affiliation":[{"name":"Neuroepidemiology Unit, Division of Neurology, Karolinska Institute,                         Huddinge University Hospital, S-141 86 Huddinge, Sweden, Division of Medical                         Statistics, Chongqing University of Medical Sciences, Chongqing, Peoples                         Republic of China,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"de Pedro-Cuesta","sequence":"additional","affiliation":[{"name":"Neuroepidemiology Unit, Division of Neurology, Karolinska Institute,                         Huddinge University Hospital, S-141 86 Huddinge, Sweden, Department of                         Applied Epidemiology, National Centre for Epidemiology, Carlos III Institute                         of Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y H","family":"Huang","sequence":"additional","affiliation":[{"name":"Neuroepidemiology Unit, Division of Neurology, Karolinska Institute,                         Huddinge University Hospital, S-141 86 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[{"name":"Neuroepidemiology Unit, Division of Neurology, Karolinska Institute,                         Huddinge University Hospital, S-141 86 Huddinge, Sweden, Division of                         Ophthalmology, Karolinska Institute, Huddinge University Hospital, S-141 86                         Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199909)46:3<296::AID-ANA4>3.0.CO;2-#"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.6.1419"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.1998.0107"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431301"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1980.tb01480.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.244"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.473"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060070098026"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.3.283"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1404"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.6.758"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.185"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270406"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050453"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.2.246"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00141-5"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.8.975"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.708"},{"key":"atypb19","unstructured":"Perkin GD                 ,                      Rose FC. 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