{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:53:14Z","timestamp":1787788394438,"version":"build-2784847793"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p> Objective: To report on the most common causes of vertigo in patients with multiple sclerosis (MS) and emphasize appro priate diagnostic techniques and treatment interventions. Background: True vertigo is estimated to occur in about 20% of MS patients. Lesions within the vestibular nuclei and in the root entry zone of cranial nerve VIII represent the most common locations where demyelinating activity can provoke vertigo in patients with MS. However, other causes of vertigo should be explored in MS patients in order to avoid unnecessar y treatment with corticosteroids and vestibular suppressants. Recently, we reviewed our four-year experience with new onset vertigo in our university-based MS population and found that benign paroxysmal positioning vertigo (BPPV) to be the most common cause. A ll patients diagnosed with BPPV were treated successfully with particle repositioning maneuvers. The remaining patients were treated with conventional therapies appro priate for the specific diagnosis. Conclusions: Empiric treatments with corticosteroids and\/or vestibular suppressants should not be employed until all MS patients undergo a careful bedside examination, which includes diagnostic positional and, if indicated, particle repositioning maneuvers. Here we emphasize the pathophysiology of BPPV and illustrate the proper techniques for the diagnostic and therapeutic maneuvers. <\/jats:p>","DOI":"10.1191\/1352458503ms901oa","type":"journal-article","created":{"date-parts":[[2003,5,20]],"date-time":"2003-05-20T22:34:08Z","timestamp":1053470048000},"page":"250-255","source":"Crossref","is-referenced-by-count":58,"title":["Benign paroxysmal positioning vertigo in multiple sclerosis: diagnosis,                 pathophysiology and therapeutic techniques"],"prefix":"10.1177","volume":"9","author":[{"given":"E M","family":"Frohman","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern Medical Center                         at Dallas, Dallas, Texas, USA, Department of Ophthalmology, University of                         Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P D","family":"Kramer","sequence":"additional","affiliation":[{"name":"New Jersey Neuroscience Institute, Seton Hall University, South Orange,                         New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Dewey","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern Medical Center                         at Dallas, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Frohman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern Medical Center                         at Dallas, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30364-5"},{"key":"atypb2","first-page":"471","volume":"28","author":"Carter S","year":"1950","journal-title":"Ass Res Nerv Dis Proc"},{"key":"atypb3","unstructured":"McAlpine D                 ,                      Lumsden CE                 ,                      Ancherson ED. Multiple sclerosis: a re-appraisal, second edition.                      London: Churchill Livingstone                 , 1972: 83-307."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1949.tb09331.x","volume":"133","author":"Muller R.","year":"1949","journal-title":"Acta Med Scand"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.6.446"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-78172-8_9"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.276"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.6.945"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.3.340"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.10.1566"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70223-1"},{"key":"atypb12","unstructured":"Leigh RJ                 ,                      Zee DS. The neurology of eye movements, second edition.                      Philadelphia, PA: FA Davis                 , 1991: 384-385."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/BF00314197","volume":"235","author":"Hopf HC.","year":"1988","journal-title":"J Neurol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.4.1107"},{"key":"atypb15","first-page":"1","volume":"315","author":"Uemura T","year":"1973","journal-title":"Acta Otolaryngol Suppl Stockh"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412107"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950181855"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1167"},{"key":"atypb19","first-page":"373","volume":"3","author":"Brandt T","year":"1993","journal-title":"J Vestib Res"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.5.796"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700310"},{"key":"atypb22","first-page":"121","volume":"25","author":"Massoud EAS","year":"1996","journal-title":"J Otolaryngol"},{"key":"atypb23","first-page":"290","volume":"42","author":"Semont A","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880160098015"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1352458503ms901oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1352458503ms901oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:25:32Z","timestamp":1740752732000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/1352458503ms901oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1191\/1352458503ms901oa"],"URL":"https:\/\/doi.org\/10.1191\/1352458503ms901oa","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}