{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:33:57Z","timestamp":1774125237946,"version":"3.50.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p> We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients. <\/jats:p>","DOI":"10.1191\/1352458503ms944oa","type":"journal-article","created":{"date-parts":[[2003,11,12]],"date-time":"2003-11-12T12:45:16Z","timestamp":1068641116000},"page":"467-471","source":"Crossref","is-referenced-by-count":19,"title":["An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients"],"prefix":"10.1177","volume":"9","author":[{"given":"L ME","family":"Grimaldi","sequence":"first","affiliation":[{"name":"Department of Neurosciences, AUSL 2 Caltanissetta, Via G. Cusmano 3,                         93100 Caltanissetta, Italy, Neuroimmunology Unit, IRCCS Ospedale San                         Raffaele, Via Olgettina 58, 20100, Milan, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pincherle","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, IRCCS Ospedale San Raffaele, Via Olgettina 58,                         20100, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Martinelli-Boneschi","sequence":"additional","affiliation":[{"name":"Neurological Department, IRCCS Ospedale San Raffaele, Via Olgettina 58,                         20100, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, IRCCS Ospedale San Raffaele, Via Olgettina                         58, 20100, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Patti","sequence":"additional","affiliation":[{"name":"Neurological Department, University of Catania, Viale A. 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