{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:15:38Z","timestamp":1770218138517,"version":"3.49.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p> This study evaluates levels of cerebrospinal fluid (C SF) brain-specific proteins (BSP) in subjects with optic neuritis (O N) who are at high risk of progression to multiple sclerosis (MS). Forty-one subjects had acute O N and 17 subjects with other neurological diseases (OND) served as controls. Twenty-o ne subjects with O N had white matter lesions on magnetic resonance imaging (MRI) and intrathecal synthesis of oligoclonal IgG bands (OB) consistent with being at high risk of progression to MS; eight of whom later were diagnosed with clinically definite MS (C DMS). Levels of S100B, ferritin and two neurofilament heavy chain phosphoforms (NfH<jats:sup>SMI34<\/jats:sup> and NfH<jats:sup>SMI35<\/jats:sup>) were analysed using ELISA technique. A putative index of \u2018axonal health\u2019 was expressed as a ratio of NfH<jats:sup>SMI34<\/jats:sup> to NfH<jats:sup>SMI35<\/jats:sup>. NfH<jats:sup>SMI34<\/jats:sup> and the NfHSMI34:SMI35 were significantly elevated in subjects with O N compared to controls. No significant differences in levels of C SF BSP were seen between O N subjects with C DMS plus those at high risk of progression to MS and O N subjects with normal MRI and negative C SF analysis. In conclusion, there is evidence of axonal damage in subjects who present with O N, which is independent of the diagnosis of C DMS. <\/jats:p>","DOI":"10.1191\/1352458504ms1020oa","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T22:51:03Z","timestamp":1084402263000},"page":"261-265","source":"Crossref","is-referenced-by-count":28,"title":["Cerebrospinal fluid levels of brain specific proteins in optic neuritis"],"prefix":"10.1177","volume":"10","author":[{"given":"E T","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Neuroinflammation, Institute of Neurology, Queen Square,                         London, WC1N 3BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation, Institute of Neurology, Queen Square,                         London, WC1N 3BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pashenkov","sequence":"additional","affiliation":[{"name":"Division of Neurology, Karolinska Institute, Huddinge University                         Hospital, Stockholm, SE-14186, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Keir","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation, Institute of Neurology, Queen Square,                         London, WC1N 3BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation, Institute of Neurology, Queen Square,                         London, WC1N 3BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Karolinska Institute, Huddinge University                         Hospital, Stockholm, SE-14186, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Giovannoni","sequence":"additional","affiliation":[{"name":"Department of Neuroinflammation, Institute of Neurology, Queen Square,                         London, WC1N 3BG, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11919-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.6.758"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.185"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011341"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.708"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050453"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90148-W"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(97)00050-1"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(03)00189-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.180"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/000456329002700504"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.10.3101"},{"key":"atypb14","first-page":"323","volume":"338","author":"Trapp 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