{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:49:47Z","timestamp":1790761787567,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p> There is much evidence of the importance of the preclinical phase of multiple sclerosis (MS). However, apart from a recent report of the incidental discovery of a case of primary progressive MS, there are no data on the sequential magnetic resonance imaging (MRI) follow-up of patients before the clinical phase. We report the incidental discovery of white matter changes on MRI and their follow-up in a patient three years before the first neurological event (optic neuritis). A 34-year-old woman presented with headaches and depression after her young daughter had been involved in a car accident and spent two weeks in intensive care. The woman\u2019s general practitioner performed a brain MRI, which revealed multiple T2-weighted hypersignals suggesting MS. During the next three years, clinical examination remained normal but we observed new T2 lesions and\/or new enhanced T1 lesions after gadolinium infusion on the four successive MRIs. Thirty-seven months after the first MRI, the patient developed a right optic neuritis. The diagnosis of MS was made according to space and time dissemination on MRI criteria. We proposed a treatment with Interferon Beta 1a (Avonex). <\/jats:p>","DOI":"10.1191\/1352458505ms1179oa","type":"journal-article","created":{"date-parts":[[2005,6,18]],"date-time":"2005-06-18T15:05:32Z","timestamp":1119107132000},"page":"395-397","source":"Crossref","is-referenced-by-count":17,"title":["Sequential magnetic resonance imaging follow-up of multiple sclerosis before                 the clinical phase"],"prefix":"10.1177","volume":"11","author":[{"given":"J","family":"de Seze","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Lille, Lille, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Vermersch","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms890cr"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050080033003"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050080031002"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.883"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.6.900"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330309"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.491"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360720"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431301"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1352458505ms1179oa","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1352458505ms1179oa","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:24:19Z","timestamp":1740806659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/1352458505ms1179oa"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1191\/1352458505ms1179oa"],"URL":"https:\/\/doi.org\/10.1191\/1352458505ms1179oa","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}