{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:12:04Z","timestamp":1791130324152,"version":"4.1.0"},"reference-count":72,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p> Many human neurological diseases involve demyelination of the central and\/or peripheral nervous systems. These include the hereditary leukodystrophies -which have a genetic basis; multiple sclerosis (MS) -where the underlying cause of demyelination remains unknown; and progressive multifocal leukoencephalopathy (PML) -where the etiology is well-established as being viral. The human neurotropic polyomavirus -JC virus (JCV) -is the etiologic agent of PML, a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients, especially those with HIV\/AIDS. JCV belongs to the polyomavirus family of tumor viruses that are characterized by non-enveloped icosahedral capsids containing small, circular, double-stranded DNA genomes. Serological studies have shown that JCV is widespread throughout the human population, but infections are usually restricted by the immune system, particularly cell-mediated immunity, causing the virus to enter a latent phase. An important corollary of this is that situations of severe immunosuppression may permit JCV to replicate and are thus a risk factor for PML. <\/jats:p>","DOI":"10.1191\/135248506ms1264oa","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T21:23:56Z","timestamp":1144099436000},"page":"133-142","source":"Crossref","is-referenced-by-count":27,"title":["Human demyelinating disease and the polyomavirus JCV"],"prefix":"10.1177","volume":"12","author":[{"given":"K","family":"Khalili","sequence":"first","affiliation":[{"name":"Center for Neurovirology and Cancer Biology, College of Science and                         Technology, Temple University, 1900 North 12th Street, 015-96, Room 203,                         Philadelphia, PA 19122, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K","family":"White","sequence":"additional","affiliation":[{"name":"Center for Neurovirology and Cancer Biology, College of Science and                    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