{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:04:38Z","timestamp":1758704678979,"version":"3.38.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p> One prognostic factor for early multiple sclerosis (MS) patients to develop a definite MS may be the presence of the MS-associated retrovirus (MSRV) in the cerebrospinal fluid (CSF). We designed a specific study on a cohort of optic neuritis (ON) patients to evaluate the MSRV-dependent conversion to MS relative to the prediction conferred by magnetic resonance imaging (MRI) and CSF abnormalities. At follow-up, 33.3% MSRV<jats:sup>+<\/jats:sup> and 0% MSRV<jats:sup>\u2212<\/jats:sup> ON patients developed MS ( P=0.03). The prediction value is lower than that given by CSF and MRI abnormalities (42.3%). This intriguing finding is discussed in the light of the abundant discrepancies observed in the MSRV literature. <\/jats:p>","DOI":"10.1191\/135248506ms1303sr","type":"journal-article","created":{"date-parts":[[2006,4,23]],"date-time":"2006-04-23T23:10:47Z","timestamp":1145833847000},"page":"357-359","source":"Crossref","is-referenced-by-count":14,"title":["Multiple sclerosis-associated retrovirus and optic neuritis"],"prefix":"10.1177","volume":"12","author":[{"given":"S","family":"Sotgiu","sequence":"first","affiliation":[{"name":"Institute of Clinical Neurology, University of Sassari, Viale San Pietro                         10, 07100 Sassari, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Arru","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neurology, University of Sassari, Viale San Pietro                         10, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Huddinge University Hospital, SE-1451 86                         Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mameli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San                         Pietro 43\/B, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San                         Pietro 43\/B, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dolei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San                         Pietro 43\/B, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410315"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.471"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1071"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1189xx"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.473"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7583"},{"key":"atypb8","first-page":"333","volume":"351","author":"Garson JA","year":"1998","journal-title":"Lancet"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1080\/13550280390173355"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.317"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/135248506ms1303sr","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/135248506ms1303sr","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:40:37Z","timestamp":1740894037000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/135248506ms1303sr"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1191\/135248506ms1303sr"],"URL":"https:\/\/doi.org\/10.1191\/135248506ms1303sr","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"type":"print","value":"1352-4585"},{"type":"electronic","value":"1477-0970"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}