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Patients with systemic sclerosis and peripheral small vessel disease have limited therapeutic options. Treprostinil is a prostacyclin analogue that can be delivered by subcutaneous infusion and is approved in the USA only for treatment of primary pulmonary hypertension. This report provides an impressive example of an alternative, complementary indication for the use of treprostinil. <\/jats:p>","DOI":"10.1191\/1358863x05vm579cr","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T00:46:57Z","timestamp":1113526017000},"page":"29-32","source":"Crossref","is-referenced-by-count":17,"title":["Treprostinil for the treatment of severe digital necrosis in systemic sclerosis"],"prefix":"10.1177","volume":"10","author":[{"given":"Gregory","family":"Engel","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley G","family":"Rockson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"atypb1","first-page":"1788","volume":"30","author":"Kotsis SV","year":"2003","journal-title":"J Rheumatol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.70.4.366"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-6-200003210-00013"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.2.151"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-6-200003210-00002"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91792-6"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.1"},{"key":"atypb8","first-page":"133","volume":"13","author":"Loosemore TM","year":"1994","journal-title":"Int Angiol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-5-199903020-00005"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.63.742.617"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.1.43"},{"key":"atypb12","first-page":"137","volume":"47","author":"Bartolone S","year":"1999","journal-title":"Minerva Cardioangiol"},{"key":"atypb13","first-page":"1433","volume":"16","author":"Langevitz P","year":"1989","journal-title":"J Rheumatol"},{"key":"atypb14","first-page":"1407","volume":"19","author":"Wigley FM","year":"1992","journal-title":"J Rheumatol"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.2340\/0001555576236238"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011223"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00721.x"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01095.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12020"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg050"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1358863x05vm579cr","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1191\/1358863x05vm579cr","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:45:24Z","timestamp":1738043124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1191\/1358863x05vm579cr"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1191\/1358863x05vm579cr"],"URL":"https:\/\/doi.org\/10.1191\/1358863x05vm579cr","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}