{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:07:16Z","timestamp":1790719636167,"version":"4.1.0"},"reference-count":25,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych Bull"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec id=\"S205646942400055X_sec_a1\"><jats:title>Aims and method<\/jats:title><jats:p>Patients prescribed clozapine are increasingly living into old age. However, there is a lack of studies to guide prescribing in this age group. We sought to identify all clozapine patients in Hertfordshire Partnership NHS Foundation Trust over a 5-year period and review side-effect burden and co-prescribing in all patients aged over 65 years.<\/jats:p><\/jats:sec><jats:sec id=\"S205646942400055X_sec_a2\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We identified 69 patients. The majority (61%) were stable in terms of mental state; 94% of cases had experienced a side-effect within the past year, with constipation occurring most commonly (65% of cases).<\/jats:p><\/jats:sec><jats:sec id=\"S205646942400055X_sec_a3\"><jats:title>Clinical implications<\/jats:title><jats:p>Our findings reveal a significant side-effect burden, particularly in relation to constipation. Clozapine-induced gastrointestinal hypomotility (CIGH) can be fatal; however, increasing age has not been a recognised risk factor for constipation in clozapine patients to date. This raises questions about increasing risk to physical health as patients age and adds to concerns about the lack of monitoring for CIGH.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjb.2024.55","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:08:49Z","timestamp":1722391729000},"page":"294-298","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of clozapine prescribing in the over-65s: 5-year retrospective study"],"prefix":"10.1192","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6697-2115","authenticated-orcid":false,"given":"James","family":"Barclay","sequence":"first","affiliation":[{"name":"Hertfordshire Partnership NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Tomar","sequence":"additional","affiliation":[{"name":"Hertfordshire Partnership NHS Foundation 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2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}