{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:36:22Z","timestamp":1792438582077,"version":"4.5.0"},"reference-count":35,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych Bull"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec id=\"S2056469425000853_as1\">\n                    <jats:title>Aims and method<\/jats:title>\n                    <jats:p>To investigate the impact of the widespread availability and use of the semi-synthetic cannabinoid hexahydrocannabinol (HHC) on hospital admissions owing to psychosis. Medical records of patients admitted for psychotic illness to University Hospital Galway were examined to assess HHC or other illicit drug use before admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056469425000853_as2\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 214 total admissions for psychotic illness, 28 admissions (13.1%) were preceded by use of HHC, nine of whom used only HHC. Sixteen (34%) admissions of first-episode psychosis were preceded by HHC use, with seven of these using only HHC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2056469425000853_as3\">\n                    <jats:title>Clinical implications<\/jats:title>\n                    <jats:p>Clinicians should explicitly enquire about the use of HHC in patients presenting with first-episode and relapse of psychotic illness. Sufficient evidence has now accumulated from research of a link between HHC and psychosis. Such psychoses appear to be more prominent in young people with early-phase psychosis, and highlights the need for authorities to change legislation to avoid further harm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjb.2025.85","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T11:41:17Z","timestamp":1752147677000},"page":"132-137","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Novel substance, same old problems: admissions of psychosis precipitated by hexahydrocannabinol, a widely available semi-synthetic cannabinoid"],"prefix":"10.1192","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-0167","authenticated-orcid":false,"given":"Brian","family":"O\u2019Mahony","sequence":"first","affiliation":[{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lanigan","sequence":"additional","affiliation":[{"name":"University Hospital Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00edall","family":"Lally","sequence":"additional","affiliation":[{"name":"University Hospital Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"University of Galway"},{"name":"University Hospital Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Smyth","sequence":"additional","affiliation":[{"name":"Trinity College Dublin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McDonald","sequence":"additional","affiliation":[{"name":"University of Galway"},{"name":"University Hospital Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hallahan","sequence":"additional","affiliation":[{"name":"University of Galway"},{"name":"University Hospital Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"S2056469425000853_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nature20153"},{"key":"S2056469425000853_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkad059"},{"key":"S2056469425000853_ref11","volume-title":"Hexahydrocannabinol (HHC) and Related Substances","year":"2023"},{"key":"S2056469425000853_ref9","doi-asserted-by":"publisher","DOI":"10.1021\/jm00376a029"},{"key":"S2056469425000853_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2010.11.001"},{"key":"S2056469425000853_ref30","first-page":"1167","article-title":"Legally flawed, scientifically problematic, potentially harmful: the UK Psychoactive Substance Bill","volume":"386","author":"Stevens","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"S2056469425000853_ref20","first-page":"44","article-title":"Prevalence study of head shop drug usage in mental health services","volume":"37","author":"Lally","year":"2013","journal-title":"Psychiatr Bull"},{"key":"S2056469425000853_ref32","volume-title":"WHO Expert Committee on Drug Dependence: Forty-Seventh Report","year":"2025"},{"key":"S2056469425000853_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.2.101"},{"key":"S2056469425000853_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2009.02.002"},{"key":"S2056469425000853_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2024.2340039"},{"key":"S2056469425000853_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20341"},{"key":"S2056469425000853_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30048-3"},{"key":"S2056469425000853_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03880.x"},{"key":"S2056469425000853_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3915-0"},{"key":"S2056469425000853_ref8","doi-asserted-by":"publisher","DOI":"10.1089\/can.2023.0143"},{"key":"S2056469425000853_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12807"},{"key":"S2056469425000853_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/ipm.2024.3"},{"key":"S2056469425000853_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05801-2"},{"key":"S2056469425000853_ref15","volume-title":"Youth Attitude on Drugs","year":"2011"},{"key":"S2056469425000853_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01478-z"},{"key":"S2056469425000853_ref6","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.23-00008"},{"key":"S2056469425000853_ref12","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2318409"},{"key":"S2056469425000853_ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-021-00398-3"},{"key":"S2056469425000853_ref1","unstructured":"1 Department of Justice and Law Reform. Misuse of Drugs Act. Government of Ireland, 1977 (https:\/\/www.irishstatutebook.ie\/eli\/1977\/act\/12\/enacted\/en\/html)."},{"key":"S2056469425000853_ref10","doi-asserted-by":"publisher","DOI":"10.1021\/jm00184a002"},{"key":"S2056469425000853_ref21","doi-asserted-by":"publisher","DOI":"10.1021\/jm00127a038"},{"key":"S2056469425000853_ref27","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.17"},{"key":"S2056469425000853_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.027"},{"key":"S2056469425000853_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/14690667231200139"},{"key":"S2056469425000853_ref14","unstructured":"14 Department of Justice and Law Reform. Criminal Justice (Psychoactive Substances) Act. Government of Ireland, 2010 (https:\/\/www.oireachtas.ie\/en\/bills\/bill\/2010\/34\/)."},{"key":"S2056469425000853_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/15332640.2011.600210"},{"key":"S2056469425000853_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0790966700011915"},{"key":"S2056469425000853_ref35","doi-asserted-by":"publisher","DOI":"10.3109\/10826089609063969"},{"key":"S2056469425000853_ref31","volume-title":"Psychoactive Substances Act","year":"2016"}],"container-title":["BJPsych Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2056469425000853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:06:57Z","timestamp":1774400817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2056469425000853\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2056469425000853"],"URL":"https:\/\/doi.org\/10.1192\/bjb.2025.85","relation":{},"ISSN":["2056-4694","2056-4708"],"issn-type":[{"value":"2056-4694","type":"print"},{"value":"2056-4708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}