{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:19:29Z","timestamp":1775150369389,"version":"3.50.1"},"reference-count":59,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec id=\"S2056472420000125_sec_a1\" sec-type=\"other\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Neurocognitive impairments robustly predict functional outcome. However, heterogeneity in neurocognition is common within diagnostic groups, and data-driven analyses reveal homogeneous neurocognitive subgroups cutting across diagnostic boundaries.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472420000125_sec_a2\" sec-type=\"other\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>To determine whether data-driven neurocognitive subgroups of young people with emerging mental disorders are associated with 3-year functional course.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472420000125_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>Model-based cluster analysis was applied to neurocognitive test scores across nine domains from 629 young people accessing mental health clinics. Cluster groups were compared on demographic, clinical and substance-use measures. Mixed-effects models explored associations between cluster-group membership and socio-occupational functioning (using the Social and Occupational Functioning Assessment Scale) over 3 years, adjusted for gender, premorbid IQ, level of education, depressive, positive, negative and manic symptoms, and diagnosis of a primary psychotic disorder.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472420000125_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Cluster analysis of neurocognitive test scores derived three subgroups described as \u2018normal range\u2019 (<jats:italic>n<\/jats:italic> = 243, 38.6%), \u2018intermediate impairment\u2019 (<jats:italic>n<\/jats:italic> = 252, 40.1%), and \u2018global impairment\u2019 (<jats:italic>n<\/jats:italic> = 134, 21.3%). The major mental disorder categories (depressive, anxiety, bipolar, psychotic and other) were represented in each neurocognitive subgroup. The global impairment subgroup had lower functioning for 3 years of follow-up; however, neither the global impairment (<jats:italic>B<\/jats:italic> = 0.26, 95% CI \u22120.67 to 1.20; <jats:italic>P<\/jats:italic> = 0.581) or intermediate impairment (<jats:italic>B<\/jats:italic> = 0.46, 95% CI \u22120.26 to 1.19; <jats:italic>P<\/jats:italic> = 0.211) subgroups differed from the normal range subgroup in their rate of change in functioning over time.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472420000125_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Neurocognitive impairment may follow a continuum of severity across the major syndrome-based mental disorders, with data-driven neurocognitive subgroups predictive of functional course. Of note, the global impairment subgroup had longstanding functional impairment despite continuing engagement with clinical services.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2020.12","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T14:19:21Z","timestamp":1584627561000},"source":"Crossref","is-referenced-by-count":25,"title":["Transdiagnostic neurocognitive subgroups and functional course in young people with emerging mental disorders: a cohort study"],"prefix":"10.1192","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-2936","authenticated-orcid":false,"given":"Jacob J.","family":"Crouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate 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