{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:18:45Z","timestamp":1789543125865,"version":"build-2803163510"},"reference-count":34,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["Early career researcher project grant"],"award-info":[{"award-number":["Early career researcher project grant"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1142045"],"award-info":[{"award-number":["1142045"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec id=\"S2056472422005907_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Factors that contribute to the early mortality observed in psychotic disorders, specifically obesity, smoking and sedentary behaviour, occur early in the disorder.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422005907_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>We aimed to determine whether the integration of a physical health nurse in the care of young people with first-episode psychosis could prevent clinically significant weight gain (\u22657% body weight). Secondary outcomes included rates of smoking, metabolic syndrome and sedentary behaviour.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422005907_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>In this single-blind, randomised controlled trial, participants who had received under 4 weeks of antipsychotic medication were randomly allocated to either the intervention (addition of a physical health nurse to their care) or treatment as usual (TAU) for 12 weeks.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422005907_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Of the 77 participants, there were follow-up data for 86.8% (<jats:italic>n<\/jats:italic> = 33) of the intervention group and 82.1% (<jats:italic>n<\/jats:italic> = 32) of the TAU group. After 12 weeks, 27.3% of the intervention group experienced clinically significant weight gain compared with 34.4% of the TAU group (odds ratio 0.72, 95% CI 0.25\u20132.06, <jats:italic>P<\/jats:italic> = 0.54). After 6 months, 40.7% of the intervention group gained clinically significant weight compared with 44.1% of the TAU group (<jats:italic>P<\/jats:italic> = 0.79). There was no difference in mean change in weight between groups after 12 weeks (2.6 kg <jats:italic>v<\/jats:italic>. 2.9 kg, <jats:italic>P<\/jats:italic> = 0.87) or 6 months (3.6 kg <jats:italic>v<\/jats:italic>. 4.3 kg, <jats:italic>P<\/jats:italic> = 0.64). There were no differences in the rates of tobacco smoking cessation, prevalence of metabolic syndrome or physical activity levels.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422005907_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>This intervention failed to prevent the metabolic complications that are highly prevalent in psychotic disorders in the short to medium term, indicating that more intensive interventions are required.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2022.590","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T07:39:32Z","timestamp":1668584372000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["A single-blind, randomised controlled trial of a physical health nurse intervention to prevent weight gain and metabolic complications in first-episode psychosis: the Physical Health Assistance in Early Psychosis (PHAstER) study"],"prefix":"10.1192","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-6952","authenticated-orcid":false,"given":"Brian","family":"O'Donoghue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Mifsud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Castagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Langstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Killackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McGorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"S2056472422005907_ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000493399"},{"key":"S2056472422005907_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.01.034"},{"key":"S2056472422005907_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12884"},{"key":"S2056472422005907_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/inm.12256"},{"key":"S2056472422005907_ref21","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"S2056472422005907_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2021.06.006"},{"key":"S2056472422005907_ref34","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13060771"},{"key":"S2056472422005907_ref6","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11r07222"},{"key":"S2056472422005907_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00137"},{"key":"S2056472422005907_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/eip.13151"},{"key":"S2056472422005907_ref20","doi-asserted-by":"publisher","DOI":"10.1080\/09595230500170266"},{"key":"S2056472422005907_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12230"},{"key":"S2056472422005907_ref3","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i8.390"},{"key":"S2056472422005907_ref27","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010079"},{"key":"S2056472422005907_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30261-3"},{"key":"S2056472422005907_ref22","volume-title":"The Scale for the Assessment of Negative Symptoms","author":"Andreasen","year":"1983"},{"key":"S2056472422005907_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30132-4"},{"key":"S2056472422005907_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.08.027"},{"key":"S2056472422005907_ref18","volume-title":"The Maudsley Prescribing Guidelines in Psychiatry","author":"Taylor","year":"2018"},{"key":"S2056472422005907_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.12.021"},{"key":"S2056472422005907_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/ipm.2020.91"},{"key":"S2056472422005907_ref23","unstructured":"23 International Diabetes Federation (IDF). 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