{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:55:44Z","timestamp":1790294144675,"version":"4.1.0"},"reference-count":46,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2314-B-532-001"],"award-info":[{"award-number":["MOST 107-2314-B-532-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2314-B-002-136-MY3"],"award-info":[{"award-number":["MOST 108-2314-B-002-136-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-532-007"],"award-info":[{"award-number":["MOST 110-2314-B-532-007"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec id=\"S2056472422006081_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422006081_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422006081_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified by age groups and used general linear models to identify associations between vitamin D and NfL levels and their interaction effects on cognitive domains.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422006081_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The mean vitamin D and NfL levels were 16.46 ng\/nL and 11.10 pg\/mL, respectively; 72% of patients were vitamin D deficient. In the older group, more frequent hospital admissions and lower physical activity were identified in the group with versus without vitamin D deficiency. The age-modified interaction effect of vitamin D and NfL was associated with composite neurocognitive scores and verbal fluency in both age groups, and with processing speed domain in the younger group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472422006081_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>We observed a high vitamin D deficiency prevalence in bipolar disorder. We identified the interaction of vitamin D and NfL on cognitive domains, and the effect was modified by age. Longitudinal or randomised controlled studies enrolling patients with various illness durations and mood statuses are required to validate our findings.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2022.608","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T08:52:57Z","timestamp":1669625577000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder"],"prefix":"10.1192","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-6472","authenticated-orcid":false,"given":"Wen-Yin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih 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