{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:28:48Z","timestamp":1790886528289,"version":"4.1.0"},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01 NR 008767-S2"],"award-info":[{"award-number":["R01 NR 008767-S2"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n\t  <jats:p>The aims of this study were: (a) to examine associations of oxytocin receptor gene (<jats:italic>OXTR<\/jats:italic>) single nucleotide polymorphisms (SNPs) with post-traumatic stress disorder (PTSD) and dissociative symptoms and (b) to investigate gene\u2013environment (G \u00d7 E) interaction with childhood maltreatment. Salivary DNA samples from 228 women of European ancestry were analysed. Two SNPs, rs237895 and rs237897, were associated with dissociative symptoms but not PTSD diagnosis. Another SNP (rs2254298) was associated with dissociation when interacting with history of childhood maltreatment. These results contribute to theorising and evidence suggesting that the oxytocin system and its genetics may be associated with risk for dissociation among European American women, including those with maltreatment history. Replication with larger patient samples, including men and other ancestry groups, is needed.<\/jats:p>","DOI":"10.1192\/bjo.2022.74","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T06:19:31Z","timestamp":1654237171000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Oxytocin receptor gene, post-traumatic stress disorder and dissociation in a community sample of European American women"],"prefix":"10.1192","volume":"8","author":[{"given":"Hyunhwa","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-6348","authenticated-orcid":false,"given":"Julia S.","family":"Seng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"S2056472422000746_ref7","volume-title":"The Oxytocin Factor: Tapping the Hormone of Calm, Love, and Healing","author":"Moberg","year":"2003"},{"key":"S2056472422000746_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nature09856"},{"key":"S2056472422000746_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/1078390313492173"},{"key":"S2056472422000746_ref3","doi-asserted-by":"publisher","DOI":"10.1080\/15299732.2010.496075"},{"key":"S2056472422000746_ref5","volume-title":"The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication, and Self-Regulation","author":"Porges","year":"2011"},{"key":"S2056472422000746_ref11","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.77"},{"key":"S2056472422000746_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12646-016-0378-2"},{"key":"S2056472422000746_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316469"},{"key":"S2056472422000746_ref2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"S2056472422000746_ref12","first-page":"89","volume-title":"Clinical Applications of the Polyvagal Theory: The Emergence of Polyvagal-Informed Therapies","author":"Tucci","year":"2018"},{"key":"S2056472422000746_ref6","doi-asserted-by":"publisher","DOI":"10.1207\/s15327965pli1701_01"},{"key":"S2056472422000746_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0886260504267759"},{"key":"S2056472422000746_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(01)00003-X"},{"key":"S2056472422000746_ref14","doi-asserted-by":"publisher","DOI":"10.1080\/15299732.2012.694594"},{"key":"S2056472422000746_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b8f8a2"}],"container-title":["BJPsych Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2056472422000746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T06:20:03Z","timestamp":1654237203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2056472422000746\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["S2056472422000746"],"URL":"https:\/\/doi.org\/10.1192\/bjo.2022.74","relation":{},"ISSN":["2056-4724"],"issn-type":[{"value":"2056-4724","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e104"}}