{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:09:57Z","timestamp":1790964597412,"version":"4.1.0"},"reference-count":44,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R155-2013-14070"],"award-info":[{"award-number":["R155-2013-14070"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["153171"],"award-info":[{"award-number":["153171"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["7-11-0213"],"award-info":[{"award-number":["7-11-0213"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec id=\"S2056472423006440_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Functional somatic disorder (FSD) is a unifying diagnosis that includes functional somatic syndromes such as irritable bowel, chronic widespread pain (CWP) and chronic fatigue. Several psychological factors are associated with FSD. However, longitudinal population-based studies elucidating the causal relationship are scarce.<\/jats:p><\/jats:sec><jats:sec id=\"S2056472423006440_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>To explore if neuroticism, perceived stress, adverse life events (ALEs) and self-efficacy can predict the development of FSD over a 5-year period.<\/jats:p><\/jats:sec><jats:sec id=\"S2056472423006440_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>A total of 4288 individuals who participated in the DanFunD baseline and 5-year follow-up investigations were included. FSD was established at both baseline and follow-up, with symptom questionnaires and diagnostic interviews. Neuroticism was measured with the short-form NEO Personality Inventory, perceived stress with the Cohen's Perceived Stress Scale, ALEs with the Danish version of the Cumulative Lifetime Adversity Measure and self-efficacy with the General Self-Efficacy Scale. Associations were investigated with multiple logistic regression models.<\/jats:p><\/jats:sec><jats:sec id=\"S2056472423006440_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Perceived stress predicted incident FSD, irritable bowel, CWP and chronic fatigue (odds ratios: 1.04\u20131.17). Neuroticism predicted incident FSD and chronic fatigue (odds ratios: 1.03\u20131.16). ALEs predicted incident FSD, CWP and chronic fatigue (odds ratios: 1.06\u20131.18). An increase in perceived stress from baseline to follow-up was associated with incident FSD, irritable bowel, CWP and chronic fatigue (odds ratios: 1.05\u20131.22). Contrary, an increase in self-efficacy seemed to be a protective factor (odds ratios: 0.89\u20130.99).<\/jats:p><\/jats:sec><jats:sec id=\"S2056472423006440_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>High neuroticism, high perceived stress and a high number of ALEs are risk factors for the development of FSD. Particularly perceived stress seems to be an important contributor to the onset of FSD.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjo.2023.644","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T08:40:12Z","timestamp":1706172012000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Neuroticism, perceived stress, adverse life events and self-efficacy as predictors of the development of functional somatic disorders: longitudinal population-based study (DanFunD)"],"prefix":"10.1192","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8141-2792","authenticated-orcid":false,"given":"Marie Weinreich","family":"Petersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Birgitte Wisbech","family":"Carstensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare Bro","family":"Wellnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u00d8rnb\u00f8l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Frostholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Meinertz","family":"Dantoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Falgaard","family":"Eplov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"S2056472423006440_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32872\/cpe.11179","article-title":"Aetiological understanding of fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome and classificatory analogues: a systematic umbrella review","volume":"5","author":"Kleinst\u00e4uber","year":"2023","journal-title":"Clin Psychol Eur"},{"key":"S2056472423006440_ref8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/PSY.0000000000000010","article-title":"Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis","volume":"76","author":"Afari","year":"2014","journal-title":"Psychosom Med"},{"key":"S2056472423006440_ref18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/00365529609006767","article-title":"Redefining abdominal syndromes. 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