{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:05:57Z","timestamp":1785521157567,"version":"3.56.0"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"unspecified","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec id=\"S2056472424007579_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Early worsening of plasma lipid levels (EWL; \u22655% change after 1 month) induced by at-risk psychotropic treatments predicts considerable exacerbation of plasma lipid levels and\/or dyslipidaemia development in the longer term.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007579_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>We aimed to determine which clinical and genetic risk factors could predict EWL.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007579_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>Predictive values of baseline clinical characteristics and dyslipidaemia-associated single nucleotide polymorphisms (SNPs) on EWL were evaluated in a discovery sample (<jats:italic>n<\/jats:italic> = 177) and replicated in two samples from the same cohort (PsyMetab; <jats:italic>n<\/jats:italic><jats:sub>1<\/jats:sub> = 176; <jats:italic>n<\/jats:italic><jats:sub>2<\/jats:sub> = 86).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007579_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Low baseline levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides, and high baseline levels of high-density lipoprotein cholesterol (HDL-C), were risk factors for early increase in total cholesterol (<jats:italic>P<\/jats:italic> = 0.002), LDL-C (<jats:italic>P<\/jats:italic> = 0.02) and triglycerides (<jats:italic>P<\/jats:italic> = 0.0006), and early decrease in HDL-C (<jats:italic>P<\/jats:italic> = 0.04). Adding genetic parameters (<jats:italic>n<\/jats:italic> = 17, 18, 19 and 16 SNPs for total cholesterol, LDL-C, HDL-C and triglycerides, respectively) improved areas under the curve for early worsening of total cholesterol (from 0.66 to 0.91), LDL-C (from 0.62 to 0.87), triglycerides (from 0.73 to 0.92) and HDL-C (from 0.69 to 0.89) (<jats:italic>P<\/jats:italic> \u2264 0.00003 in discovery sample). The additive value of genetics to predict early worsening of LDL-C levels was confirmed in two replication samples (<jats:italic>P<\/jats:italic> \u2264 0.004). In the combined sample (<jats:italic>n<\/jats:italic> \u2265 203), adding genetics improved the prediction of new-onset dyslipidaemia for total cholesterol, LDL-C and HDL-C (<jats:italic>P<\/jats:italic> \u2264 0.04).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007579_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Clinical and genetic factors contributed to the prediction of EWL and new-onset dyslipidaemia in three samples of patients who started at-risk psychotropic treatments. Future larger studies should be conducted to refine SNP estimates to be integrated into clinically applicable predictive models.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2024.757","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:49:21Z","timestamp":1733395761000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Lipid disturbances induced by psychotropic drugs: clinical and genetic predictors for early worsening of lipid levels and new-onset dyslipidaemia in Swiss psychiatric 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