{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:04:32Z","timestamp":1774328672123,"version":"3.50.1"},"reference-count":54,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011738","name":"Lee Kong Chian School of Medicine, Nanyang Technological University","doi-asserted-by":"publisher","award":["Fellowship grant"],"award-info":[{"award-number":["Fellowship grant"]}],"id":[{"id":"10.13039\/501100011738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["SICS EPI Grant and SST Grant No. C221618002"],"award-info":[{"award-number":["SICS EPI Grant and SST Grant No. C221618002"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec id=\"S2056472424007671_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Childhood maltreatment and peer victimisation are common sources of early-life interpersonal stress. Childhood maltreatment is associated with atypical frontolimbic emotion processing and regulation, and increased vulnerability for self-harm\/suicide. However, few studies have compared the neurofunctional correlates between caregiver- versus peer-inflicted mistreatment.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007671_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>We compared the alterations of neurofunctional correlates of facial emotion processing in youths exposed to childhood maltreatment or peer victimisation, and explored their associations with self-harm.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007671_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>Functional magnetic resonance imaging data were collected from 114 age- and gender-matched youths (39 childhood maltreatment, 37 peer victimisation and 38 controls) during an emotion discrimination task. Region-of-interest (amygdala, insula) and whole-brain analyses were conducted.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007671_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Groups differed significantly during disgust processing only. Both groups had lower activation in the right amygdala and bilateral posterior insula than controls; left insular underactivation was furthermore related to increased self-harm in maltreated youths. Compared with controls, at the whole-brain level, both groups also had underactivation in a cluster of bilateral limbic-thalamic-striatal, precuneus\/posterior cingulate, temporal, fusiform\/lingual and cerebellar regions, which was negatively associated with emotional problems in controls, as well as a cluster of somatosensory regions associated with increased self-harm in maltreated youths.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424007671_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Early-life interpersonal stress from caregivers or peers is associated with common underactivation of limbic-thalamic-striatal, precuneus\/posterior cingulate and somatosensory regions during disgust processing. The hypoactivation of key emotion and sensory processing and self-referential brain regions could be a potential suppressive mechanism to cope with the aversive emotion; however, it may also entail increased risk of affective psychopathology in seemingly healthy youths.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2024.767","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T10:22:54Z","timestamp":1730110974000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Common neural correlates of disgust processing in childhood maltreatment and peer victimisation"],"prefix":"10.1192","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-923X","authenticated-orcid":false,"given":"Lena","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Rubia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Lukito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"S2056472424007671_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2006.09.002"},{"key":"S2056472424007671_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/psyrad\/kkab020"},{"key":"S2056472424007671_ref52","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"S2056472424007671_ref15","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13101401"},{"key":"S2056472424007671_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(02)00174-3"},{"key":"S2056472424007671_ref1","unstructured":"1 World Health Organization (WHO). 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