{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:04:36Z","timestamp":1788563076818,"version":"build-2803163510"},"reference-count":39,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B 189240"],"award-info":[{"award-number":["32003B 189240"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec id=\"S205647242400797X_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Investigations of computerised cognitive training (CCT) show heterogeneous results in slowing age-related cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242400797X_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To comprehensively evaluate the effectiveness of serious games-based CCT, integrating control conditions, neurophysiological and blood-based biomarkers, and subjective measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242400797X_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this bi-centric randomised controlled trial with parallel groups, 160 participants (mean age 71.3 years) with cognitive impairment ranging from subjective decline to mild cognitive impairment, were pseudo-randomised to three arms: an intervention group receiving CCT immediately, an active control (watching documentaries) and a waitlist condition, which both started the CCT intervention after the control period. Both active arms entailed a 3-month intervention period comprising a total of 60 at-home sessions (five per week) and weekly on-site group meetings. In the intervention group, this was followed by additional 6 months of CCT, with monthly booster sessions to assess long-term training effects. Behavioural and subjective changes were assessed in 3-month intervals. Biological effects were measured by amyloid blood markers and magnetic resonance imaging obtained before and after training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242400797X_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adherence to the training protocol was consistently high across groups and time points (4.87 sessions per week). Domain-specific cognitive scores showed no significant interaction between groups and time points. Significant cognitive and subjective improvements were observed after long-term training. Voxel-based morphometry revealed no significant changes in grey matter volume following CCT, nor did amyloid levels moderate its effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S205647242400797X_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates no benefits of 3 months of CCT on cognitive or biological outcomes. However, positive effects were observed subjectively and after long-term CCT, warranting the inclusion of CCT in multicomponent interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjo.2024.797","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T03:47:36Z","timestamp":1730864856000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial"],"prefix":"10.1192","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-7697","authenticated-orcid":false,"given":"Esther","family":"Brill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Holfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Falkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-6834","authenticated-orcid":false,"given":"Anna-Katharine","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"S205647242400797X_ref28","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000314810.46029.74"},{"key":"S205647242400797X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"S205647242400797X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.01.034"},{"key":"S205647242400797X_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2850.2011.01735.x"},{"key":"S205647242400797X_ref12","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181020"},{"key":"S205647242400797X_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"S205647242400797X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.012"},{"key":"S205647242400797X_ref32","doi-asserted-by":"publisher","DOI":"10.1002\/alz.064069"},{"key":"S205647242400797X_ref14","first-page":"CD010775","article-title":"Montreal cognitive assessment for the detection of dementia","volume":"7","author":"Davis","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"S205647242400797X_ref18","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.128.4.612"},{"key":"S205647242400797X_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79948-3_1153"},{"key":"S205647242400797X_ref20","doi-asserted-by":"publisher","DOI":"10.1037\/a0028228"},{"key":"S205647242400797X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"S205647242400797X_ref23","first-page":"206","article-title":"Le test de copie d'une figure complexe; 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e200"}}