{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:16:37Z","timestamp":1792653397927,"version":"4.5.0"},"reference-count":83,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec id=\"S2056472424008056_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Various studies have highlighted the increased incidence and symptoms of depression and anxiety in paediatric cancer survivors (PCS). Yet no meta-analysis has focused on post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in PCS and their family nucleus.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008056_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>To evaluate the overall risk of PTSD and severity of PTSS in PCS and their family nucleus. Secondary objectives include identifying potential risk factors of PTSD and high PTSS.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008056_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>We systematically searched PubMed, Embase and PsycINFO for studies comparing the risk of PTSD and PTSS severity among PCS, their family nucleus and non-cancer controls. PRISMA reporting guidelines were followed. Random effects meta-analyses and meta-regressions were conducted.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008056_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>From 1089 records, we included 21 studies. PCS have an increased risk of PTSD (risk ratio 2.36, 95% CI 1.37\u20134.06) and decreased PTSS severity (standardised mean difference \u22120.29, 95% CI \u22120.50 to \u22120.08). Subgroup analyses of other categorical study-level characteristics revealed that female PCS who were older at diagnosis and data collection had a significantly higher risk of PTSD. Meta-regression were insignificant. Family nucleus did not show a significantly increased risk of PTSD (risk ratio 1.13, 95% CI 0.59\u20135.00) and PTSS severity (standardised mean difference 0.53, 95% CI \u22120.00 to 1.06). Systematically reviewing studies on the family nucleus found that the majority reported a significantly increased risk of psychological trauma compared with the comparator. Lower education, income and social status were also risk factors.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008056_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Timely identification and interventions are imperative for policy makers and healthcare providers to prevent trauma from worsening in this population group.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2024.805","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T07:03:53Z","timestamp":1731308633000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression"],"prefix":"10.1192","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-0984","authenticated-orcid":false,"given":"Chen 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