{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:45:05Z","timestamp":1782315905177,"version":"3.54.5"},"reference-count":41,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec id=\"S2056472424008299_sec_a1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008299_sec_a2\">\n\t    <jats:title>Aims<\/jats:title>\n\t    <jats:p>To describe the organisation, patient cohort and acceptability of the remote diagnostic and interventional procedures.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008299_sec_a3\" sec-type=\"methods\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>We describe the recruitment, consultation set-up, the clinical and biomarker programme, and the two online group interventions for cognitive wellbeing and lifestyle change. We evaluate the acceptability of the remote consultations, lumbar puncture, saliva genotyping, and remote cognitive and functional assessments.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008299_sec_a4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>We present the results of the first 68 (mean age 73, 55% female, 43% minoritised ethnicity) of 146 people who enrolled for full remote clinical, cognitive, genetic, cerebrospinal fluid and neuroimaging phenotyping. A total of 86% were very satisfied\/satisfied with the remote service. In all, 67% consented to lumbar puncture, and 95% of those were very satisfied, all having no significant complications. A total of 93% found taking saliva genotyping very easy\/easy, and 93% found the cognitive assessments instructions clear. In all, 98% were satisfied with the Cognitive Wellbeing Group, and 90% of goals were achieved in the Lifestyle Intervention Group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2056472424008299_sec_a5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The SLaM BHC provides a highly acceptable and safe clinical model for remote assessments and lumbar punctures in a representative, ethnically diverse population. This allows early and accurate diagnosis of Alzheimer's disease, differentiation from other MCI causes and targets modifiable risk factors. This is crucial for future disease modification, ensuring equitable access to research, and provides precise, timely and cost-efficient diagnoses in UK mental health services.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/bjo.2024.829","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:44:27Z","timestamp":1734587067000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust"],"prefix":"10.1192","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-1948","authenticated-orcid":false,"given":"Ashwin V.","family":"Venkataraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Kandangwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos","family":"Lemmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutvi","family":"Savla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Beigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Harwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Velayudhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-6834","authenticated-orcid":false,"given":"Anna-Katharine","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kalafatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-216X","authenticated-orcid":false,"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"S2056472424008299_ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.706695"},{"key":"S2056472424008299_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100576"},{"key":"S2056472424008299_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01736-x"},{"key":"S2056472424008299_ref35","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2418298"},{"key":"S2056472424008299_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.8.1091"},{"key":"S2056472424008299_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610219001881"},{"key":"S2056472424008299_ref34","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00403-3"},{"key":"S2056472424008299_ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.579934"},{"key":"S2056472424008299_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"S2056472424008299_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/13558196231211141"},{"key":"S2056472424008299_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37709-x"},{"key":"S2056472424008299_ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1210974"},{"key":"S2056472424008299_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.1661"},{"key":"S2056472424008299_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"S2056472424008299_ref26","unstructured":"26 South London and Maudsley NHS Trust. Consent for Contact. South London and Maudsley NHS Trust, 2020 (https:\/\/slam.nhs.uk\/consent-for-contact)."},{"key":"S2056472424008299_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(23)00214-1"},{"key":"S2056472424008299_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"S2056472424008299_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"S2056472424008299_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac013"},{"key":"S2056472424008299_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"S2056472424008299_ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0348-0"},{"key":"S2056472424008299_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12470"},{"key":"S2056472424008299_ref20","first-page":"7","article-title":"Detection rates of mild cognitive impairment in primary care for the United States medicare population","volume":"11","author":"Liu","year":"2023","journal-title":"J Prev Alzheimers Dis"},{"key":"S2056472424008299_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700005742"},{"key":"S2056472424008299_ref40","first-page":"329","article-title":"Validation, deployment, and real-world implementation of a modular toolbox for Alzheimer's disease detection and dementia risk reduction: the AD-RIDDLE project","volume":"11","author":"Malzbender","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"S2056472424008299_ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0891988719882102"},{"key":"S2056472424008299_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa228"},{"key":"S2056472424008299_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab173"},{"key":"S2056472424008299_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/25.2.113"},{"key":"S2056472424008299_ref36","unstructured":"36 Venkataraman, A . SLaM Image Bank. NIHR Maudsley Biomedical Reserach Centre, South London and Maudsley NHS Foundation Trust, 2024 (https:\/\/www.brainregion.com\/slamimagebank)."},{"key":"S2056472424008299_ref22","doi-asserted-by":"publisher","DOI":"10.1177\/0891988708328214"},{"key":"S2056472424008299_ref7","unstructured":"7 Cook, L , Souris, H , Isaacs, J . The 2019 National Memory Service Audit. NHS London Clinical Networks, 2020 (https:\/\/www.england.nhs.uk\/london\/wp-content\/uploads\/sites\/8\/2020\/04\/The-2019-national-memory-service-audit.pdf)."},{"key":"S2056472424008299_ref38","first-page":"29","article-title":"Multidomain interventions to prevent cognitive impairment, Alzheimer's disease, and dementia: from FINGER to world-wide FINGERS","volume":"7","author":"Rosenberg","year":"2020","journal-title":"J Prev Alzheimers Dis"},{"key":"S2056472424008299_ref12","article-title":"Automated brain image analysis in dementia using artificial intelligence: a roadmap for the development of clinical tools","author":"Venkataraman","year":"2023","journal-title":"OSF Preprints"},{"key":"S2056472424008299_ref21","unstructured":"21 Digi-Inclusion, 2021 (https:\/\/digiinclusion.wixsite.com\/london [cited 18 Jan 2024])."},{"key":"S2056472424008299_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2023.166"},{"key":"S2056472424008299_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"S2056472424008299_ref18","unstructured":"18 Alzheimer's Research UK. Detecting and Diagnosing Alzheimer's Disease. Alzheimer's Research UK, 2020 (https:\/\/www.alzheimersresearchuk.org\/about-us\/our-influence\/policy-work\/reports\/detecting-diagnosing-alzheimers-disease-2020\/ [cited 27 Oct 2023])."},{"key":"S2056472424008299_ref33","first-page":"78","article-title":"Polygenic risk scoring is an effective approach to predict those individuals most likely to decline cognitively due to Alzheimer's disease","volume":"8","author":"Daunt","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"S2056472424008299_ref39","unstructured":"39 Alzheimer-Europe. PREDICTOM Project Secures EUR 21 Million Investment to Pioneer Early Alzheimer's Detection. Alzheimer-Europe, 2023 (https:\/\/www.alzheimer-europe.org\/news\/predictom-project-secures-eur-21-million-investment-pioneer-early-alzheimers-detection [cited 17 Jan 2024])."},{"key":"S2056472424008299_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00269-x"}],"container-title":["BJPsych Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2056472424008299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:44:32Z","timestamp":1734587072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2056472424008299\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["S2056472424008299"],"URL":"https:\/\/doi.org\/10.1192\/bjo.2024.829","relation":{},"ISSN":["2056-4724"],"issn-type":[{"value":"2056-4724","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e8"}}